Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | BCHE | P06276 | 3/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.50 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10923607 | 0.99 | L3MBTL1 (0.54) | L3MBTL1BCHEALOX5NOX1PARP10 | |
| Bromide SCHEMBL10558009 | 0.93 | L3MBTL1 (0.51) | L3MBTL1BCHEALOX5NOX1PARP10 | |
| Bromide SCHEMBL10648631 | 0.92 | L3MBTL1 (0.52) | L3MBTL1BCHEALOX5NOX1PARP10 | |
| SCHEMBL10922439 | 0.92 | L3MBTL1 (0.52) | L3MBTL1BCHEALOX5NOX1PARP10 | |
| Bromide SCHEMBL10556732 | 0.91 | BCHE (0.54) | L3MBTL1BCHEALOX5NOX1PARP10 | |
| SCHEMBL10922348 | 0.90 | BCHE (0.55) | L3MBTL1BCHEALOX5NOX1PARP10 | |
| Bromide SCHEMBL10557453 | 0.84 | ALOX5 (0.48) | L3MBTL1BCHEALOX5NOX1PARP10 | |
| SCHEMBL9375612 | 0.84 | NOX1 (0.59) | L3MBTL1ALOX5NOX1PARP10MAOB | |
| Bromide SCHEMBL10556202 | 0.84 | TP53 (0.51) | KCNH2 | |
| Bromide SCHEMBL10557009 | 0.84 | ALOX5 (0.50) | L3MBTL1BCHEALOX5NOX1PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4847269-A | GLAUCOMA, AMIDES OR UREA DERIVATIVES OF AMINOETHYLCARBOXY COMPOUNDS | SYNTEX (U.S.A.) INC. (US) | 1989-07-11 | — | — | US | disclosed |
| US-4629730-A | ADMINISTERING DIALKYL OR CYCLOAKYL AMINO ETHYLANILINE DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1986-12-16 | — | — | US | disclosed |