Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 10/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10502251 | 0.83 | PDE4A (0.43) | ADORA2BADORA2AADORA1 | |
| SCHEMBL10556767 | 0.83 | ADORA3 (0.50) | ADORA2BADORA2AADORA1ADORA3 | |
| SCHEMBL10564345 | 0.82 | ADORA3 (0.49) | ADORA2BADORA2AADORA1ADORA3 | |
| SCHEMBL10560783 | 0.81 | ADORA2A (0.43) | ADORA2BADORA2AADORA1ADORA3ALDH1A1 | |
| SCHEMBL10561092 | 0.80 | ADORA1 (0.44) | ADORA2BADORA2AADORA1ADORA3 | |
| SCHEMBL10558873 | 0.79 | ADORA2A (0.46) | ADORA2BADORA2AADORA1ADORA3ALDH1A1 | |
| SCHEMBL10560097 | 0.79 | ADORA2B (0.44) | ADORA2BADORA2AADORA1ADORA3ALDH1A1 | |
| SCHEMBL10557634 | 0.79 | ADORA3 (0.47) | ADORA2BADORA2AADORA1ADORA3ALDH1A1 | |
| SCHEMBL10560947 | 0.78 | ADORA3 (0.52) | ADORA2AADORA1ADORA3ALDH1A1KDM4E | |
| SCHEMBL10558207 | 0.78 | HSD17B10 (0.46) | ADORA2BADORA2AADORA1ADORA3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4824848-A | TREATMENT, PREVENTION OF NERVOUS SYSTEM DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0237289-A2 | Pyrazolo [3,4-d] pyrimidine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1987-09-16 | — | — | EP | disclosed |