Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8752419 | 0.81 | MAPT (0.68) | ALDH1A1MAPTRAB9AHTTHSD17B10 | |
| SCHEMBL8752469 | 0.78 | ALDH1A1 (0.68) | ALDH1A1MAPTRAB9AHTTHSD17B10 | |
| SCHEMBL1968295 | 0.77 | HDAC3 (0.53) | ALDH1A1MAPTRAB9AHTTHSD17B10 | |
| SCHEMBL1712196 | 0.76 | GSK3B (0.48) | ALDH1A1MAPTRAB9ANPC1L3MBTL1 | |
| SCHEMBL1711929 | 0.76 | NPC1 (0.47) | ALDH1A1MAPTRAB9AHTTSMN1; SMN2 | |
| SCHEMBL1712729 | 0.76 | TDP1 (0.47) | ALDH1A1MAPTRAB9AHIF1ASMN1; SMN2 | |
| SCHEMBL10580254 | 0.76 | ALDH1A1 (0.57) | ALDH1A1MAPTRAB9AHTTHSD17B10 | |
| SCHEMBL7922185 | 0.75 | HTT (0.68) | ALDH1A1MAPTRAB9AHTTHSD17B10 | |
| SCHEMBL11116780 | 0.73 | ALDH1A1 (0.72) | ALDH1A1MAPTRAB9AHTTHSD17B10 | |
| SCHEMBL1712359 | 0.73 | GSK3B (0.51) | ALDH1A1MAPTRAB9APOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4820819-A | 5-phenyl-3[2H]-pyridazinone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-04-11 | — | — | US | disclosed |
| US-4678786-A | Pharmaceutical compositions having β-adrenoceptor antagonist activity employing pyridazinone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-07-07 | — | — | US | disclosed |
| EP-0138344-A2 | Pyridazinones as beta-adrenoceptor antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-04-24 | — | — | EP | disclosed |
| US-4474787-A | 7,6 Dioxo-4H,6H-pyrano[3,2-g]quinoline dicarboxylic acids and anti-allergic use thereof | FISONS LIMITED (GB) | 1984-10-02 | — | — | US | disclosed |