Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.47 |
| ▸ | TACR2 | P21452 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SHBG | P04278 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15005593 | 0.80 | CA2 (0.56) | ESR1ESR2TAAR1SLC6A2ADRA2A | |
| SCHEMBL2136637 | 0.80 | SLC6A4 (0.52) | TAAR1SLC6A2HTR3ASLC6A4SLC6A3 | |
| SCHEMBL22129795 | 0.80 | TAAR1 (0.48) | TAAR1KDM4EL3MBTL1KMT2AS1PR1 | |
| SCHEMBL22137305 | 0.80 | S1PR1 (0.41) | SLC6A4CYP3A4S1PR1S1PR2S1PR3 | |
| SCHEMBL895572 | 0.79 | SLC6A2 (0.63) | ESR1ESR2TAAR1SLC6A2ADRA2A | |
| SCHEMBL980709 | 0.79 | ESR1 (0.54) | ESR1ESR2TAAR1SLC6A2ADRA2A | |
| SCHEMBL896162 | 0.79 | SLC6A2 (0.63) | ESR1ESR2TAAR1SLC6A2ADRA2A | |
| SCHEMBL44507 | 0.79 | SLC6A2 (0.63) | ESR1ESR2TAAR1SLC6A2ADRA2A | |
| SCHEMBL13452965 | 0.79 | ANPEP (0.48) | TAAR1SLC6A2SLC6A4SLC6A3TP53 | |
| SCHEMBL1148969 | 0.79 | ANPEP (0.48) | TAAR1SLC6A2SLC6A4SLC6A3TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4845127-A | ANTIBESITY | ELI LILLY AND COMPANY (US) | 1989-07-04 | — | — | US | disclosed |
| US-4391826-A | DIETETICS | ELI LILLY AND COMPANY (US) | 1983-07-05 | — | — | US | disclosed |
| EP-0007204-B1 | PHENETHANOLAMINES, THEIR FORMULATIONS, USE AND PREPARATION | ELI LILLY AND COMPANY (US) | 1982-11-24 | — | — | EP | disclosed |
| EP-0007204-A1 | Phenethanolamines, their formulations, use and preparation | ELI LILLY AND COMPANY (US) | 1980-01-23 | — | — | EP | disclosed |