Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 2/20 | 0.65 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.65 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.65 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL105647 | 1.00 | PDK1 (0.65) | PDK1PDK2PDK3PDK4MAPK14 | |
| SCHEMBL13810588 | 1.00 | PDK1 (0.65) | PDK1PDK2PDK3PDK4MAPK14 | |
| SCHEMBL107382 | 1.00 | PDK1 (0.65) | PDK1PDK2PDK3PDK4MAPK14 | |
| SCHEMBL30294995 | 0.94 | PDK1 (0.58) | PDK1PDK2PDK3PDK4MAPK14 | |
| SCHEMBL25482534 | 0.89 | PDK1 (0.52) | PDK1PDK2PDK3PDK4MAPK14 | |
| SCHEMBL21563560 | 0.89 | PDK1 (0.52) | PDK1PDK2PDK3PDK4MAPK14 | |
| SCHEMBL13732893 | 0.89 | PDK1 (0.52) | PDK1PDK2PDK3PDK4MAPK14 | |
| SCHEMBL21563420 | 0.89 | PDK1 (0.52) | PDK1PDK2PDK3PDK4MAPK14 | |
| SCHEMBL21563422 | 0.89 | PDK1 (0.52) | PDK1PDK2PDK3PDK4MAPK14 | |
| SCHEMBL13731232 | 0.89 | PDK1 (0.52) | PDK1PDK2PDK3PDK4MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426113-B1 | CARBINOL COMPOUND HAVING HETEROCYCLIC LINKER | KOWA CO (JP) | 2013-11-06 | — | — | EP | disclosed |
| US-8551985-B2 | Carbinol derivatives having heterocyclic linker | KOWA COMPANY, LTD. (JP) | 2013-10-08 | — | — | US | disclosed |
| EP-2426113-A1 | CARBINOL COMPOUND HAVING HETEROCYCLIC LINKER | Kowa Company, Ltd. (JP) | 2012-03-07 | — | — | EP | disclosed |
| US-20100280013-A1 | CARBINOL DERIVATIVES HAVING HETEROCYCLIC LINKER | KOWA COMPANY, LTD. (JP) | 2010-11-04 | — | — | US | disclosed |
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280013-A1 | CARBINOL DERIVATIVES HAVING HETEROCYCLIC LINKER | NR1H2, NR1H3, CCR2 | PDK1 3459/4885PDK2 2979/4885PDK3 3455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.