Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.37 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.37 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.37 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.37 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.37 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.37 |
| ▸ | FXYD2 | P54710 | 1/20 | 0.37 |
| ▸ | ATP1A4 | Q13733 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | S100B | P04271 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10564960 | 1.00 | ALDH1A1 (0.39) | ALDH1A1MAPTKDM4CTSHRL3MBTL1 | |
| SCHEMBL10563780 | 0.80 | ATP1A1 (0.43) | ALDH1A1MAPTKDM4CTHRBATP1A1 | |
| SCHEMBL10563776 | 0.80 | ATP1A1 (0.43) | ALDH1A1MAPTKDM4CTHRBATP1A1 | |
| SCHEMBL10568294 | 0.79 | TSHR (0.50) | ALDH1A1MAPTKDM4CTSHRL3MBTL1 | |
| SCHEMBL10569574 | 0.79 | ALDH1A1 (0.44) | ALDH1A1MAPTKDM4CTSHRL3MBTL1 | |
| SCHEMBL10567768 | 0.79 | CYP3A4 (0.40) | ALDH1A1MAPTKDM4CTSHRL3MBTL1 | |
| SCHEMBL10569570 | 0.79 | ALDH1A1 (0.44) | ALDH1A1MAPTKDM4CTSHRL3MBTL1 | |
| SCHEMBL10568707 | 0.79 | CYP19A1 (0.41) | ALDH1A1MAPTKDM4CTSHRL3MBTL1 | |
| SCHEMBL10567774 | 0.79 | CYP3A4 (0.40) | ALDH1A1MAPTKDM4CTSHRL3MBTL1 | |
| SCHEMBL10568700 | 0.79 | CYP19A1 (0.41) | ALDH1A1MAPTKDM4CTSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4824851-A | Pyrimidones as cardiotonic, anti hypertensive, cerebrovascular vasodilator and anti-platelet agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-25 | — | — | US | disclosed |
| US-4746664-A | Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-05-24 | — | — | US | disclosed |
| EP-0123402-A2 | Pyrimidine derivatives, preparation thereof and use thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-10-31 | — | — | EP | disclosed |