Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.71 |
| ▸ | DRD2 | P14416 | 1/20 | 0.71 |
| ▸ | HTR2A | P28223 | 1/20 | 0.71 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.71 |
| ▸ | HTR7 | P34969 | 1/20 | 0.71 |
| ▸ | HRH1 | P35367 | 1/20 | 0.71 |
| ▸ | DRD3 | P35462 | 1/20 | 0.71 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.57 |
| ▸ | PARP1 | P09874 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10567502 | 0.94 | HTR1A (0.68) | HTR1ADRD2HTR2ASLC6A4HTR7 | |
| SCHEMBL10562412 | 0.92 | HTR1A (0.71) | HTR1ADRD2HTR2ASLC6A4HTR7 | |
| SCHEMBL10566753 | 0.88 | HTR1A (0.58) | HTR1ADRD2HTR2ASLC6A4HTR7 | |
| Hydrochloric Acid SCHEMBL10566982 | 0.88 | HTR1A (0.58) | HTR1ADRD2HTR2ASLC6A4HTR7 | |
| SCHEMBL10564874 | 0.87 | HTR1A (0.53) | HTR1ADRD2HTR2ASLC6A4HTR7 | |
| SCHEMBL10566347 | 0.87 | HTR1A (0.53) | HTR1ADRD2HTR2ASLC6A4HTR7 | |
| SCHEMBL10569881 | 0.86 | SIGMAR1 (0.54) | HTR1ADRD2HTR2ASLC6A4HTR7 | |
| SCHEMBL10569937 | 0.86 | HTR1A (0.52) | HTR1ADRD2HTR2ASLC6A4HTR7 | |
| SCHEMBL10568056 | 0.85 | KDM4E (0.61) | HTR1ADRD2HTR2ASLC6A4HTR7 | |
| SCHEMBL10568897 | 0.85 | KDM4E (0.52) | HTR1ADRD2HTR2ASLC6A4HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4824852-A | Substituted indole compounds which have useful effects on the central nervous system | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1989-04-25 | — | — | US | disclosed |
| US-4740602-A | Indole derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1988-04-26 | — | — | US | disclosed |
| EP-0206225-A2 | Indole derivatives | MERCK PATENT GmbH (DE) | 1986-12-30 | — | — | EP | disclosed |