Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10567238 | 0.81 | TDP2 (0.43) | TDP2MAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL10563573 | 0.81 | TDP2 (0.44) | TDP2MAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL9833078 | 0.78 | TDP2 (0.49) | TDP2MAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL9834438 | 0.78 | TDP2 (0.49) | TDP2MAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL9833486 | 0.78 | TDP2 (0.45) | TDP2MAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL10566884 | 0.77 | TDP2 (0.40) | TDP2MAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL10568216 | 0.77 | TDP2 (0.42) | TDP2MAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL10566814 | 0.77 | TDP2 (0.42) | TDP2MAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL9833956 | 0.76 | KDM4E (0.52) | TDP2MAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL10567141 | 0.75 | TDP2 (0.37) | TDP2MAPTL3MBTL1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4835280-A | Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-30 | — | — | US | disclosed |
| US-4695567-A | Pyrrolobenzimidazoles, pharmaceutical compositions containing them and method of using them to treat certain heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1987-09-22 | — | — | US | disclosed |
| EP-0189103-A2 | Pyrrolo-benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1986-07-30 | — | — | EP | disclosed |