Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9832287 | 0.90 | KDM4E (0.41) | TDP2ALDH1A1MAPTL3MBTL1KDM4E | |
| SCHEMBL9833956 | 0.87 | KDM4E (0.52) | TDP2ALDH1A1MAPTL3MBTL1KDM4E | |
| SCHEMBL9830572 | 0.83 | ALDH1A1 (0.42) | ALDH1A1MAPTKDM4EGAAKMT2A | |
| SCHEMBL9834438 | 0.83 | TDP2 (0.49) | TDP2ALDH1A1MAPTL3MBTL1KDM4E | |
| SCHEMBL10571719 | 0.82 | TDP2 (0.43) | TDP2ALDH1A1MAPTL3MBTL1KDM4E | |
| SCHEMBL10563573 | 0.81 | TDP2 (0.44) | TDP2ALDH1A1MAPTL3MBTL1KDM4E | |
| SCHEMBL9833078 | 0.81 | TDP2 (0.49) | TDP2ALDH1A1MAPTL3MBTL1KDM4E | |
| SCHEMBL10567238 | 0.80 | TDP2 (0.43) | TDP2ALDH1A1MAPTL3MBTL1KDM4E | |
| SCHEMBL10566814 | 0.79 | TDP2 (0.42) | TDP2ALDH1A1MAPTL3MBTL1KDM4E | |
| SCHEMBL10568216 | 0.79 | TDP2 (0.42) | TDP2ALDH1A1MAPTL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161632-B1 | PYRROLO-BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND INTERMEDIATES | Roche Diagnostics GmbH (DE) | 1991-04-10 | — | — | EP | disclosed |
| US-4963686-A | INTERMEDIATES FOR INOTROPIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1990-10-16 | — | — | US | disclosed |