Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 19/20 | 0.47 |
| ▸ | GSK3A | P49840 | 3/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10567051 | 0.99 | GSK3B (0.46) | GSK3BGSK3ACDK1CDK2MAP4K4 | |
| SCHEMBL6478219 | 0.68 | GSK3B (0.58) | GSK3BGSK3ACDK1CDK2MAP4K4 | |
| SCHEMBL7175630 | 0.68 | NR4A2 (0.39) | DYRK1A | |
| SCHEMBL1461484 | 0.68 | GSK3B (0.70) | GSK3BGSK3ACDK1CDK2MAP4K4 | |
| SCHEMBL8358236 | 0.67 | GNG2 (0.73) | — | |
| SCHEMBL18330351 | 0.66 | CYP2C19 (0.55) | GSK3BGSK3ACDK1CDK2MAP4K4 | |
| SCHEMBL1461503 | 0.66 | GSK3B (0.59) | GSK3BGSK3ACDK1CDK2MAP4K4 | |
| SCHEMBL1377394 | 0.65 | GSK3B (0.58) | GSK3BGSK3ACDK1CDK2MAP4K4 | |
| SCHEMBL14786138 | 0.65 | CHRM4 (0.55) | GSK3BGSK3ACDK1CDK2MAP4K4 | |
| SCHEMBL6478145 | 0.64 | GSK3B (1.00) | GSK3BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4833136-A | ANTIINFLAMMATORY AGENTS | BEECHAM GROUP P.L.C. (GB) | 1989-05-23 | — | — | US | claimed |
| EP-0239191-A2 | Pyrazolo[4,3-b]pyridine derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1987-09-30 | — | — | EP | claimed |
| US-4833136-A | ANTIINFLAMMATORY AGENTS | BEECHAM GROUP P.L.C. (GB) | 1989-05-23 | — | — | US | disclosed |
| EP-0239191-A2 | Pyrazolo[4,3-b]pyridine derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1987-09-30 | — | — | EP | disclosed |