Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 2/20 | 0.30 |
| ▸ | MAOB | P27338 | 2/20 | 0.30 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.30 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9134809 | 0.73 | ALDH1A1 (0.40) | ALDH1A1RECQLTDP1MEN1MAPT | |
| SCHEMBL28647073 | 0.70 | TDP1 (0.48) | ALDH1A1RECQLTDP1MEN1MAPT | |
| SCHEMBL27594442 | 0.69 | TDP1 (0.40) | ALDH1A1RECQLTDP1MEN1MAPT | |
| SCHEMBL7606757 | 0.69 | ERBB2 (0.41) | ALDH1A1RECQLTDP1MEN1MAPT | |
| SCHEMBL16887861 | 0.69 | ALDH1A1 (0.40) | ALDH1A1RECQLTDP1MEN1MAPT | |
| SCHEMBL28033967 | 0.65 | ALDH1A1 (0.34) | ALDH1A1RECQLTDP1MEN1MAPT | |
| SCHEMBL27992527 | 0.65 | ALDH1A1 (0.37) | ALDH1A1RECQLTDP1MEN1MAPT | |
| SCHEMBL15630516 | 0.64 | ALDH1A1 (0.36) | ALDH1A1RECQLTDP1MEN1MAPT | |
| SCHEMBL21814436 | 0.64 | ACHE (0.38) | ALDH1A1RECQLTDP1MEN1MAPT | |
| SCHEMBL16887859 | 0.64 | ALDH1A1 (0.36) | ALDH1A1RECQLTDP1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4795812-A | ANTITUMOR | THE UPJOHN COMPANY (US) | 1989-01-03 | — | — | US | disclosed |
| EP-0210228-A1 | 4-SUBSTITUTED-6-ARYL PYRIMIDINE COMPOUNDS | THE UPJOHN COMPANY (US) | 1987-02-04 | — | — | EP | disclosed |
| WO-1986004583-A1 | 4-SUBSTITUTED-6-ARYL PYRIMIDINE COMPOUNDS | THE UPJOHN COMPANY (US) | 1986-08-14 | — | — | WO | disclosed |