Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 4/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10569614 | 0.78 | FFAR4 (0.48) | ALDH1A1KDM4EMAPTHSD17B10FFAR4 | |
| SCHEMBL10570943 | 0.78 | KDM4E (0.40) | EPAS1ALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL28563540 | 0.70 | MAPT (0.60) | EPAS1ALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL30987223 | 0.70 | MAPT (0.60) | EPAS1ALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL28167685 | 0.68 | EPAS1 (0.57) | EPAS1ALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL8140189 | 0.66 | EPAS1 (0.50) | EPAS1ALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL14339474 | 0.66 | KDM4E (0.50) | CYP17A1CYP19A1CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL28072438 | 0.65 | KDM4E (0.46) | EPAS1ALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL11352516 | 0.64 | MAPT (0.41) | EPAS1ALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL6964514 | 0.63 | KDM4E (0.52) | EPAS1ALDH1A1KDM4EMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4868188-A | 4-(Benzisothiazol-3-yl)phenoxyacetic acid 1',1'-dioxides as diuretics | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-09-19 | — | — | US | disclosed |
| EP-0110169-A2 | 4-(Benzisothiazol-3-yl)phenoxyacetic-acid l',l'-dioxides, a process for preparing the same, intermediates thereof and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1984-06-13 | — | — | EP | disclosed |