Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10567993 | 0.78 | EPAS1 (0.39) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL10569614 | 0.74 | FFAR4 (0.48) | KDM4EMAPTALDH1A1HSD17B10HTT | |
| SCHEMBL30987223 | 0.73 | MAPT (0.60) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL28563540 | 0.73 | MAPT (0.60) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL3626867 | 0.68 | MAPT (0.42) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL7609903 | 0.67 | MAPT (0.43) | KDM4EMAPTALDH1A1HSD17B10MAPK1 | |
| SCHEMBL6964514 | 0.66 | KDM4E (0.52) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL23909388 | 0.66 | CYP3A4 (0.50) | KDM4EMAPTALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL6273598 | 0.66 | CYP3A4 (0.60) | MAPTALDH1A1HSD17B10CYP3A4MAPK1 | |
| SCHEMBL291121 | 0.66 | KDM4E (0.56) | KDM4EMAPTALDH1A1HSD17B10EPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4868188-A | 4-(Benzisothiazol-3-yl)phenoxyacetic acid 1',1'-dioxides as diuretics | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-09-19 | — | — | US | disclosed |
| EP-0110169-A2 | 4-(Benzisothiazol-3-yl)phenoxyacetic-acid l',l'-dioxides, a process for preparing the same, intermediates thereof and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1984-06-13 | — | — | EP | disclosed |