Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 3/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.52 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.52 |
| ▸ | CLK2 | P49760 | 1/20 | 0.52 |
| ▸ | CLK3 | P49761 | 1/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.52 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | CHUK | O15111 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17913502 | 1.00 | MKNK1 (0.53) | MKNK1MKNK2CLK1CDK5DYRK1A | |
| SCHEMBL17913360 | 1.00 | MKNK1 (0.53) | MKNK1MKNK2CLK1CDK5DYRK1A | |
| SCHEMBL30497341 | 0.90 | KDM4E (0.46) | MKNK1MKNK2CLK1CDK5DYRK1A | |
| SCHEMBL18427749 | 0.84 | IRAK4 (0.69) | MKNK1MKNK2IRAK4 | |
| SCHEMBL30196438 | 0.84 | IRAK4 (0.69) | MKNK1MKNK2IRAK4 | |
| SCHEMBL30497329 | 0.84 | IRAK4 (0.46) | MKNK1MKNK2CLK1CDK5DYRK1A | |
| SCHEMBL17142212 | 0.81 | NPC1 (0.56) | KDM4ENPC1MAPTTSHRRAB9A | |
| SCHEMBL8584230 | 0.80 | ALDH1A1 (0.71) | KDM4ENPC1MAPTTSHRRAB9A | |
| SCHEMBL1271246 | 0.80 | MAOA (0.59) | IKBKBCHUKKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL9881345 | 0.80 | SIRT3 (0.59) | MKNK1MKNK2CLK1CDK5DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3536685-B1 | BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS AND THEIR USE AS IRAK4 INHIBITORS | PFIZER (US) | 2022-02-16 | — | — | EP | claimed |
| WO-2024194756-A1 | MODULATING THE INNATE IMMUNITY OF RNA | PFIZER INC. (US) | 2024-09-26 | — | — | WO | disclosed |
| EP-4125900-A1 | METHODS OF TREATING CORONAVIRUS DISEASE 2019 | Pfizer Inc. (US) | 2023-02-08 | — | — | EP | disclosed |