Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.35 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10563558 | 0.82 | TDP2 (0.41) | TDP2ALDH1A1MAPTL3MBTL1PKN1 | |
| SCHEMBL9834430 | 0.82 | TDP2 (0.45) | TDP2ALDH1A1MAPTL3MBTL1KDM4E | |
| SCHEMBL9833477 | 0.81 | PKN1 (0.54) | TDP2ALDH1A1MAPTL3MBTL1PKN1 | |
| SCHEMBL9833068 | 0.81 | TDP2 (0.44) | TDP2ALDH1A1MAPTL3MBTL1PKN1 | |
| SCHEMBL10566801 | 0.80 | TDP2 (0.40) | TDP2ALDH1A1MAPTL3MBTL1PKN1 | |
| SCHEMBL10566874 | 0.79 | TDP2 (0.37) | TDP2ALDH1A1MAPTL3MBTL1PKN1 | |
| SCHEMBL10567219 | 0.79 | TDP2 (0.39) | TDP2ALDH1A1MAPTL3MBTL1PKN1 | |
| SCHEMBL10567141 | 0.79 | TDP2 (0.37) | TDP2ALDH1A1MAPTL3MBTL1PKN1 | |
| SCHEMBL9833942 | 0.78 | KDM4E (0.47) | ALDH1A1MAPTPKN1PKN2KDM4E | |
| SCHEMBL10571709 | 0.78 | SIRT2 (0.39) | TDP2ALDH1A1MAPTL3MBTL1PKN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4835280-A | Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-30 | — | — | US | disclosed |
| US-4695567-A | Pyrrolobenzimidazoles, pharmaceutical compositions containing them and method of using them to treat certain heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1987-09-22 | — | — | US | disclosed |
| EP-0189103-A2 | Pyrrolo-benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1986-07-30 | — | — | EP | disclosed |