⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14683321 | 1.00 | — | — | |
| SCHEMBL14530229 | 1.00 | — | — | |
| Iodide SCHEMBL38650964 | 0.98 | — | — | |
| SCHEMBL1299314 | 0.86 | — | — | |
| SCHEMBL763837 | 0.86 | — | — | |
| SCHEMBL464560 | 0.84 | — | — | |
| Hydrochloric Acid SCHEMBL3001802 | 0.82 | NCF1 (0.37) | — | |
| Hydrochloric Acid SCHEMBL28677617 | 0.82 | NCF1 (0.37) | — | |
| Bromide SCHEMBL29093254 | 0.82 | NCF1 (0.37) | — | |
| SCHEMBL18745661 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104583217-B | Substituted thiophene-fused and furan-fused oxazolopyrimidine-5- (6H) -one compounds | 达特神经科学(开曼)有限公司 | 2017-11-17 | — | — | CN | claimed |
| EP-2861605-B1 | 6-Benzyl-6H-thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5-one derivatives as phosphodiesterase-1 (PDE-1) inhibitors for the treatment of e.g. neurological, cognitive and cardiovascular disorders | DART NEUROSCIENCE (CAYMAN) LTD (KY) | 2017-05-03 | — | — | EP | claimed |
| US-9499562-B2 | Substituted thiophene- and furan-fused azolopyrimidine-5-(6H)-one compounds | DART NEUROSCIENCE (CAYMAN) LTD. (KY) | 2016-11-22 | — | — | US | claimed |
| US-20160031901-A1 | SUBSTITUTED THIOPHENE- AND FURAN-FUSED AZOLOPYRIMIDINE-5-(6H)-ONE COMPOUNDS | DART NEUROSCIENCE LLC | 2016-02-04 | — | — | US | claimed |
| CN-104583217-A | Substituted thiophene-fused and furan-fused oxazolopyrimidine-5- (6H) -one compounds | DART NEUROSCIENCE CAYMAN LTD | 2015-04-29 | — | — | CN | claimed |
| WO-2023034836-A1 | COMPOUNDS AND METHODS FOR MODULATING SPLICING | REMIX THERAPEUTICS INC. (US) | 2023-03-09 | — | — | WO | disclosed |
| CN-114072412-B | Tricyclic compound, pharmaceutical composition and application thereof | 深圳铂立健医药有限公司 | 2023-01-10 | — | — | CN | disclosed |
| CN-114072412-A | Tricyclic compound, pharmaceutical composition and application thereof | 深圳铂立健医药有限公司 | 2022-02-18 | — | — | CN | disclosed |
| EP-3916003-A1 | N-METHYL-D-ASPARTATE RECEPTOR MODULATORS AND METHODS OF MAKING AND USING SAME | Naurex, Inc. (US) | 2021-12-01 | — | — | EP | disclosed |
| US-20210277175-A1 | AMINE FOR LOW-EMISSION EPOXY RESIN COMPOSITIONS | SIKA TECHNOLOGY AG (CH) | 2021-09-09 | — | — | US | disclosed |
| CN-109641895-B | Indole compounds substituted with [1, 2, 4] triazolo [1, 5-a ] pyridyl | 百时美施贵宝公司 | 2021-09-03 | — | — | CN | disclosed |
| CN-113214294-A | Tricyclic compound, pharmaceutical composition and application thereof | 深圳铂立健医药有限公司 | 2021-08-06 | — | — | CN | disclosed |
| US-8299086-B2 | Pyrimidine derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-10-30 | — | — | US | disclosed |
| CN-102711476-A | Novel tricyclic compounds | ABBOTT LAB | 2012-10-03 | — | — | CN | disclosed |
| EP-2271643-B1 | OXADIAZOLES AS S1P1 RECEPTOR AGONISTS | GLAXO GROUP LTD (GB) | 2012-08-15 | — | — | EP | disclosed |
| US-20100234346-A1 | NOVEL PYRIMIDINE DERIVATIVES | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-09-16 | — | — | US | disclosed |
| US-20080004314-A1 | Phenylpiperidines and Phenylpyrrolidines | APODACA RICHARD L | 2008-01-03 | — | — | US | disclosed |
| US-7279491-B2 | Phenylpiperidines and phenylpyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-09 | — | — | US | disclosed |
| US-4835164-A | HYPOTENSIVE AGENTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-30 | — | — | US | disclosed |
| EP-0279707-A2 | Aryloxymethyl derivatives of nitrogenous heterocyclic methanols and ethers thereof having cardiovascular activity | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-08-24 | — | — | EP | disclosed |