Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 16/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 11/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12931258 | 0.80 | AURKA (0.46) | AURKAPDE2AAURKBCYP2C9CYP2C19 | |
| SCHEMBL3532491 | 0.79 | AURKA (0.49) | AURKAAURKB | |
| SCHEMBL1052514 | 0.77 | GPR4 (0.32) | — | |
| SCHEMBL1056113 | 0.77 | AURKA (0.45) | AURKAAURKB | |
| SCHEMBL12931268 | 0.77 | AURKA (0.42) | AURKAPDE2AAURKBCYP2C9CYP2C19 | |
| Trifluoroacetic Acid SCHEMBL1052723 | 0.77 | AURKA (0.44) | AURKAPDE2AAURKBCYP2C9CYP2C19 | |
| SCHEMBL1056138 | 0.71 | PDE10A (0.33) | — | |
| SCHEMBL12931365 | 0.65 | AURKA (0.51) | AURKAAURKB | |
| SCHEMBL23792672 | 0.64 | AURKA (0.72) | AURKAAURKB | |
| SCHEMBL401827 | 0.63 | P2RX7 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254888-B1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | MSD KK (JP) | 2014-12-24 | — | — | EP | disclosed |
| US-8519136-B2 | Aminopyridine derivatives having aurora a selective inhibitory action | MSD K.K. (JP) | 2013-08-27 | — | — | US | disclosed |
| US-20110003833-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2011-01-06 | — | — | US | disclosed |
| EP-2254888-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | Banyu Pharmaceutical Co., Ltd. (JP) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009104802-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2009-08-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003833-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | AURKA, AURKC, AURKB | AURKA 1/4885PDE2A 2264/4885AURKB 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.