Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10567229 | 0.85 | PDE4A (0.56) | ALOX5EPHX2ALDH1A1RAB9AKDM4E | |
| SCHEMBL10373500 | 0.81 | PDE4A (0.51) | ALDH1A1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL9832933 | 0.78 | PDE4A (0.65) | ALDH1A1RAB9AKDM4EMAPTHSD17B10 | |
| SCHEMBL9832117 | 0.77 | MAPT (0.54) | EPHX2ALDH1A1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL9833966 | 0.76 | MAPT (0.40) | ALDH1A1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL10530446 | 0.74 | CHEK1 (0.49) | ALOX5EPHX2ALDH1A1RAB9AKDM4E | |
| SCHEMBL10698980 | 0.73 | AURKA (0.57) | ALOX5EPHX2ALDH1A1RAB9AKDM4E | |
| SCHEMBL10566214 | 0.73 | ALOX5 (0.52) | ALOX5EPHX2ALDH1A1RAB9AKDM4E | |
| SCHEMBL10373365 | 0.72 | PDE2A (0.45) | ALDH1A1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL10699765 | 0.72 | AURKA (0.48) | ALOX5EPHX2ALDH1A1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4835280-A | Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-30 | — | — | US | disclosed |
| US-4695567-A | Pyrrolobenzimidazoles, pharmaceutical compositions containing them and method of using them to treat certain heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1987-09-22 | — | — | US | disclosed |
| EP-0189103-A2 | Pyrrolo-benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1986-07-30 | — | — | EP | disclosed |