Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10699765 | 0.92 | AURKA (0.48) | AURKAAURKBCHEK1LIMK1CDK5 | |
| SCHEMBL10531369 | 0.82 | ALDH1A1 (0.46) | AURKAAURKBCHEK1LIMK1CDK5 | |
| SCHEMBL10700901 | 0.81 | AURKA (0.57) | AURKAAURKBCHEK1PDE10ABRD4 | |
| SCHEMBL10698085 | 0.80 | AURKA (0.58) | AURKAAURKBCHEK1RAB9ANPC1 | |
| SCHEMBL10696602 | 0.80 | AURKA (0.60) | AURKAAURKBCHEK1ALDH1A1POLB | |
| SCHEMBL10701072 | 0.79 | AURKA (0.59) | AURKAAURKBCHEK1BRD4 | |
| SCHEMBL10700349 | 0.79 | AURKA (0.62) | AURKAAURKBMAPTKMT2APKM | |
| SCHEMBL10698143 | 0.79 | AURKA (0.59) | AURKAAURKBCHEK1ALDH1A1MAPT | |
| SCHEMBL10698507 | 0.79 | AURKB (0.59) | AURKAAURKBCHEK1LIMK1CDK5 | |
| Hydrochloric Acid SCHEMBL10699432 | 0.78 | AURKA (0.56) | AURKAAURKBCHEK1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |