Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.48 |
| ▸ | DRD2 | P14416 | 7/20 | 0.47 |
| ▸ | DRD3 | P35462 | 5/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10572119 | 0.86 | HTR1A (0.57) | HTR1ADRD2DRD3DRD1DRD5 | |
| SCHEMBL10572762 | 0.84 | MAPT (0.51) | — | |
| SCHEMBL10570087 | 0.82 | HTR1A (0.47) | HTR1ADRD2DRD3DRD1DRD5 | |
| SCHEMBL10570155 | 0.81 | HTR1A (0.57) | HTR1ADRD2DRD3DRD4ADRB2 | |
| SCHEMBL11064799 | 0.77 | TMEM97 (0.53) | DRD2DRD3DRD4ADRB2CHRM2 | |
| SCHEMBL10575317 | 0.72 | SIGMAR1 (0.54) | HTR1ADRD2DRD3DRD1DRD5 | |
| SCHEMBL10569223 | 0.72 | SIGMAR1 (0.56) | HTR1ADRD2DRD3DRD1DRD5 | |
| SCHEMBL10573223 | 0.72 | DRD3 (0.60) | HTR1ADRD2DRD3ADRA1ASIGMAR1 | |
| SCHEMBL10569856 | 0.71 | MAPT (0.59) | ADRB2ADRB1 | |
| Hydrochloric Acid SCHEMBL10668121 | 0.70 | MAPT (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4824840-A | ANTIHISTAMINES, NERVOUS SYSTEM CONTROLLERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-25 | — | — | US | disclosed |
| US-4734416-A | ANTIHISTAMINES, CENTRAL NERVOUS SYSTEM CONTROLLING ACTION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-29 | — | — | US | disclosed |