Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.87 |
| ▸ | MAOA | P21397 | 9/20 | 0.74 |
| ▸ | MAOB | P27338 | 9/20 | 0.74 |
| ▸ | DRD4 | P21917 | 3/20 | 0.68 |
| ▸ | DRD3 | P35462 | 3/20 | 0.68 |
| ▸ | HTR1A | P08908 | 1/20 | 0.68 |
| ▸ | DRD1 | P21728 | 1/20 | 0.68 |
| ▸ | DRD5 | P21918 | 1/20 | 0.68 |
| ▸ | HTR2A | P28223 | 1/20 | 0.68 |
| ▸ | HTR2C | P28335 | 1/20 | 0.68 |
| ▸ | HTR2B | P41595 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10571607 | 0.96 | DRD2 (0.94) | DRD2MAOAMAOBDRD4DRD3 | |
| Hydrochloric Acid SCHEMBL10572620 | 0.95 | DRD2 (0.92) | DRD2MAOAMAOBDRD4DRD3 | |
| SCHEMBL10571057 | 0.93 | DRD2 (0.75) | DRD2MAOAMAOBDRD4DRD3 | |
| SCHEMBL10665990 | 0.93 | DRD2 (1.00) | DRD2MAOAMAOBDRD4DRD3 | |
| SCHEMBL10576593 | 0.92 | DRD2 (0.98) | DRD2MAOAMAOBDRD4DRD3 | |
| SCHEMBL10572654 | 0.91 | DRD2 (0.88) | DRD2MAOAMAOBDRD4DRD3 | |
| SCHEMBL23097595 | 0.89 | DRD2 (0.81) | DRD2MAOAMAOBDRD4DRD3 | |
| SCHEMBL10571214 | 0.87 | MAOA (0.94) | DRD2MAOAMAOBDRD4DRD3 | |
| SCHEMBL10428487 | 0.86 | DRD2 (0.77) | DRD2MAOAMAOBDRD4DRD3 | |
| SCHEMBL10428627 | 0.86 | DRD2 (0.76) | DRD2MAOAMAOBDRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4824840-A | ANTIHISTAMINES, NERVOUS SYSTEM CONTROLLERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-25 | — | — | US | disclosed |
| US-4734416-A | ANTIHISTAMINES, CENTRAL NERVOUS SYSTEM CONTROLLING ACTION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-29 | — | — | US | disclosed |