Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 4/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | TACR2 | P21452 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SHBG | P04278 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10566495 | 0.97 | IGF1R (0.47) | SLC28A3IGF1RALOX15CALM1ESR1 | |
| SCHEMBL10569707 | 0.90 | ESR1 (0.50) | SLC28A3IGF1RALOX15ESR1ESR2 | |
| SCHEMBL10566942 | 0.83 | HRH3 (0.49) | GPR84TAAR1 | |
| SCHEMBL10564786 | 0.80 | CALM1 (0.50) | IGF1RALOX15CALM1ESR1ESR2 | |
| SCHEMBL10565636 | 0.79 | HRH3 (0.53) | IGF1RALOX15GPR84 | |
| SCHEMBL245139 | 0.73 | ESR1 (0.77) | SLC28A3IGF1RALOX15CALM1ESR1 | |
| SCHEMBL1171041 | 0.73 | ESR1 (0.77) | SLC28A3IGF1RALOX15CALM1ESR1 | |
| SCHEMBL10563288 | 0.72 | TAAR1 (0.50) | GPR84BACE1TAAR1NPC1RAB9A | |
| SCHEMBL10567365 | 0.69 | AOC3 (0.42) | — | |
| SCHEMBL10569187 | 0.69 | DAO (0.50) | IGF1RALOX15CALM1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0302603-A1 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1989-02-08 | — | — | EP | claimed |
| US-4798843-A | HYPOTENSIVE AGENTS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-01-17 | — | — | US | claimed |
| EP-0302603-A1 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1989-02-08 | — | — | EP | disclosed |
| US-4798843-A | HYPOTENSIVE AGENTS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-01-17 | — | — | US | disclosed |