Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | DAO | P14920 | 3/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | BRS3 | P32247 | 1/20 | 0.40 |
| ▸ | COMT | P21964 | 1/20 | 0.40 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.40 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.40 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10565636 | 0.96 | HRH3 (0.53) | HRH3DAOGPR84AOC3PDE10A | |
| SCHEMBL10563288 | 0.89 | TAAR1 (0.50) | HRH3DAOGPR84AOC3PDE10A | |
| SCHEMBL10569546 | 0.83 | SLC28A3 (0.46) | GPR84TAAR1 | |
| SCHEMBL10565813 | 0.81 | AOC3 (0.62) | HRH3DAOAOC3PDE10ABRS3 | |
| SCHEMBL10564786 | 0.79 | CALM1 (0.50) | HRH3DAOTAAR1 | |
| SCHEMBL12522164 | 0.75 | BRS3 (0.51) | HRH3DAOGPR84BRS3KDM6B | |
| SCHEMBL23812457 | 0.74 | AOC3 (0.67) | HRH3DAOGPR84AOC3 | |
| SCHEMBL10569707 | 0.71 | ESR1 (0.50) | GPR84TAAR1 | |
| SCHEMBL9217891 | 0.71 | BRS3 (0.48) | HRH3DAOPDE10ABRS3 | |
| SCHEMBL28353517 | 0.71 | HTR2A (0.64) | HTR2ATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4798843-A | HYPOTENSIVE AGENTS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-01-17 | — | — | US | claimed |
| EP-0302603-A1 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1989-02-08 | — | — | EP | disclosed |
| US-4798843-A | HYPOTENSIVE AGENTS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-01-17 | — | — | US | disclosed |