Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 18/20 | 0.94 |
| ▸ | DRD3 | P35462 | 8/20 | 0.82 |
| ▸ | DRD4 | P21917 | 7/20 | 0.82 |
| ▸ | MAOA | P21397 | 3/20 | 0.82 |
| ▸ | HTR1A | P08908 | 2/20 | 0.82 |
| ▸ | DRD1 | P21728 | 2/20 | 0.82 |
| ▸ | DRD5 | P21918 | 2/20 | 0.82 |
| ▸ | HTR2A | P28223 | 2/20 | 0.82 |
| ▸ | HTR2C | P28335 | 2/20 | 0.82 |
| ▸ | HTR2B | P41595 | 2/20 | 0.82 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.82 |
| ▸ | MEN1 | O00255 | 1/20 | 0.82 |
| ▸ | MLNR | O43193 | 1/20 | 0.82 |
| ▸ | HTR3B | O95264 | 1/20 | 0.82 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.82 |
| ▸ | ESR1 | P03372 | 1/20 | 0.82 |
| ▸ | PGR | P06401 | 1/20 | 0.82 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.82 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.82 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13532795 | 0.97 | DRD2 (1.00) | DRD2DRD3DRD4MAOAHTR1A | |
| SCHEMBL10569615 | 0.95 | DRD2 (0.89) | DRD2DRD3DRD4MAOAHTR1A | |
| SCHEMBL23097785 | 0.93 | DRD2 (0.82) | DRD2DRD3DRD4MAOAHTR1A | |
| Aripiprazole SCHEMBL29438823 | 0.91 | DRD2 (1.00) | DRD2DRD3DRD4MAOAHTR1A | |
| Aripiprazole SCHEMBL29356997 | 0.91 | DRD2 (1.00) | DRD2DRD3DRD4MAOAHTR1A | |
| Aripiprazole SCHEMBL8255 | 0.91 | DRD2 (1.00) | DRD2DRD3DRD4MAOAHTR1A | |
| Aripiprazole SCHEMBL982189 | 0.91 | DRD2 (1.00) | DRD2DRD3DRD4MAOAHTR1A | |
| Aripiprazole SCHEMBL29475637 | 0.91 | DRD2 (1.00) | DRD2DRD3DRD4MAOAHTR1A | |
| Aripiprazole SCHEMBL29475638 | 0.91 | DRD2 (1.00) | DRD2DRD3DRD4MAOAHTR1A | |
| SCHEMBL251238 | 0.90 | DRD2 (1.00) | DRD2DRD3DRD4MAOAHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4734416-A | ANTIHISTAMINES, CENTRAL NERVOUS SYSTEM CONTROLLING ACTION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-29 | — | — | US | claimed |
| US-4824840-A | ANTIHISTAMINES, NERVOUS SYSTEM CONTROLLERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-25 | — | — | US | disclosed |
| US-4734416-A | ANTIHISTAMINES, CENTRAL NERVOUS SYSTEM CONTROLLING ACTION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-29 | — | — | US | disclosed |