Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | SCN1A | P35498 | 2/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.34 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.34 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.34 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11282871 | 0.74 | ADRB1 (0.49) | HTR1AOPRK1ADRB2ADRB1SCN1A | |
| SCHEMBL10573123 | 0.73 | ADRB2 (0.44) | HTR1AOPRK1ADRB2ADRB1SCN1A | |
| SCHEMBL10572437 | 0.72 | HRH3 (0.49) | HTR1AOPRK1ADRB2ADRB1DRD2 | |
| SCHEMBL11285594 | 0.72 | ADRB1 (0.47) | HTR1AOPRK1ADRB2ADRB1SCN1A | |
| SCHEMBL1764193 | 0.72 | ADRB2 (0.57) | HTR1AOPRK1ADRB2ADRB1DRD2 | |
| SCHEMBL9653563 | 0.72 | ADRB1 (0.49) | HTR1AOPRK1ADRB2ADRB1SCN1A | |
| SCHEMBL11539715 | 0.71 | HTR2C (0.46) | HTR1AADRB1SLC6A2SLC6A4KCNH2 | |
| SCHEMBL11283090 | 0.71 | ADRB2 (0.48) | HTR1AOPRK1ADRB2ADRB1KDM4E | |
| SCHEMBL27691792 | 0.70 | ADRB1 (0.53) | HTR1AOPRK1ADRB2ADRB1SCN1A | |
| SCHEMBL30636067 | 0.70 | ADRB2 (0.51) | HTR1AOPRK1ADRB2ADRB1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4824840-A | ANTIHISTAMINES, NERVOUS SYSTEM CONTROLLERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-25 | — | — | US | disclosed |