Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.55 |
| ▸ | GSK3A | P49840 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | STAT6 | P42226 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10571865 | 0.85 | GAA (0.52) | GSK3BGSK3AKMT2AALDH1A1MEN1 | |
| SCHEMBL8487839 | 0.76 | KMT2A (0.62) | KMT2AALDH1A1MEN1GAACYP1A2 | |
| SCHEMBL13898851 | 0.76 | KMT2A (0.62) | KMT2AALDH1A1MEN1GAACYP1A2 | |
| SCHEMBL14275843 | 0.71 | ALDH1A1 (0.55) | GSK3BGSK3AKMT2AALDH1A1MEN1 | |
| SCHEMBL338442 | 0.71 | GSK3A (1.00) | GSK3BGSK3AKMT2AALDH1A1MEN1 | |
| SCHEMBL28469209 | 0.71 | KMT2A (0.64) | KMT2AALDH1A1MEN1GAACYP1A2 | |
| SCHEMBL22247509 | 0.70 | KMT2A (0.63) | GSK3BGSK3AKMT2AALDH1A1MEN1 | |
| SCHEMBL5179725 | 0.69 | ALDH1A1 (0.60) | KMT2AALDH1A1MEN1GAACYP1A2 | |
| SCHEMBL10574135 | 0.69 | GSK3A (0.70) | GSK3BGSK3AKMT2AALDH1A1MEN1 | |
| SCHEMBL22426223 | 0.69 | ALDH1A1 (0.60) | KMT2AALDH1A1MEN1GAACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4746738-A | SKIN THICKENERS | WELLA AKTIENGESELLSCHAFT (DE) | 1988-05-24 | — | — | US | claimed |
| EP-0116318-B1 | TETRAHYDRO-1,3-THIAZINE-2,4-DIONES, THEIR USE AND AGENTS CONTAINING THESE COMPOUNDS FOR THE TREATMENT OF THE SKIN | Wella Aktiengesellschaft (DE) | 1988-03-02 | — | — | EP | claimed |
| EP-0116318-A1 | Tetrahydro-1,3-thiazine-2,4-diones, their use and agents containing these compounds for the treatment of the skin | Wella Aktiengesellschaft (DE) | 1984-08-22 | — | — | EP | claimed |
| WO-1984003041-A1 | TETRAHYDRO-1,3-THIAZIN-2,4-DIONE, UTILIZATION THEREOF AND SKIN TREATING AGENTS CONTAINING SAID COMPOUND | WELLA AG (DE) | 1984-08-16 | — | — | WO | claimed |
| US-4883652-A | THICKEN EPIDERMIS, PROTECTIVE COATING, ANTIAGING | WELLA AKTIENGESELLSCHAFT (DE) | 1989-11-28 | — | — | US | disclosed |
| US-4746738-A | SKIN THICKENERS | WELLA AKTIENGESELLSCHAFT (DE) | 1988-05-24 | — | — | US | disclosed |
| EP-0116318-B1 | TETRAHYDRO-1,3-THIAZINE-2,4-DIONES, THEIR USE AND AGENTS CONTAINING THESE COMPOUNDS FOR THE TREATMENT OF THE SKIN | Wella Aktiengesellschaft (DE) | 1988-03-02 | — | — | EP | disclosed |
| EP-0116318-A1 | Tetrahydro-1,3-thiazine-2,4-diones, their use and agents containing these compounds for the treatment of the skin | Wella Aktiengesellschaft (DE) | 1984-08-22 | — | — | EP | disclosed |