Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 5/20 | 1.00 |
| ▸ | GSK3B | P49841 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | PIM1 | P11309 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | F2 | P00734 | 1/20 | 0.53 |
| ▸ | PLG | P00747 | 1/20 | 0.53 |
| ▸ | ELANE | P08246 | 1/20 | 0.53 |
| ▸ | CTSG | P08311 | 1/20 | 0.53 |
| ▸ | CMA1 | P23946 | 1/20 | 0.53 |
| ▸ | CTRC | Q99895 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MGLL | Q99685 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7252535 | 0.90 | GSK3A (0.82) | GSK3AGSK3BALDH1A1POLBPIM1 | |
| SCHEMBL5457409 | 0.90 | GSK3A (0.81) | GSK3AGSK3BALDH1A1POLBPIM1 | |
| SCHEMBL6992265 | 0.89 | GSK3A (0.79) | GSK3AGSK3BALDH1A1POLBPIM1 | |
| SCHEMBL5455147 | 0.86 | GSK3A (0.74) | GSK3AGSK3BALDH1A1POLBPIM1 | |
| SCHEMBL5455190 | 0.86 | GSK3A (0.74) | GSK3AGSK3BALDH1A1POLBPIM1 | |
| SCHEMBL5455188 | 0.86 | GSK3A (0.74) | GSK3AGSK3BALDH1A1POLBPIM1 | |
| SCHEMBL5462796 | 0.86 | GSK3A (0.74) | GSK3AGSK3BALDH1A1POLBPIM1 | |
| SCHEMBL5455104 | 0.84 | GSK3A (0.71) | GSK3AGSK3BALDH1A1POLBPIM1 | |
| SCHEMBL5454906 | 0.84 | GSK3A (0.72) | GSK3AGSK3BALDH1A1POLBPIM1 | |
| SCHEMBL8499789 | 0.83 | GSK3A (0.70) | GSK3AGSK3BALDH1A1POLBPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 384 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070065472-A1 | Benzyl-1,3-thiazolidine-2,4-dione compounds for stimulating or inducing the growth and/or for reducing the loss of keratin fibers | L'OREAL (FR) | 2007-03-22 | — | — | US | claimed |
| US-20070059260-A1 | Benzyl-1,3-thiazolidine-2,4-dione compounds for promoting and/or inducing and/or stimulating the pigmentation of keratin materials and/or for limiting their depigmentation and/or whitening | L'OREAL (FR) | 2007-03-15 | — | — | US | claimed |
| EP-1738742-A2 | Benzyl-1,3-thiazolidine-2,4-dione compounds, compositions comprising them and use for stimulating or inducing the growth of keratinic fibres and/or for diminsihing their loss | L'Oréal (FR) | 2007-01-03 | — | — | EP | claimed |
| EP-1738740-A2 | Use of benzyl-1,3-thiazolidine-2,4-dione compounds for favouring and/or inducing and/or stimulating the pigmentation of keratinic materials and/or for limiting their depigmentation and/or their bleaching | L'Oréal (FR) | 2007-01-03 | — | — | EP | claimed |
| US-7091359-B2 | Process for the preparation of thiazolidinedione derivatives | SMITHKLINE BEECHAM PLC (GB) | 2006-08-15 | — | — | US | claimed |
| EP-1207157-B1 | SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES | KYORIN SEIYAKU KK (JP) | 2005-06-01 | — | — | EP | claimed |
| EP-1207158-B1 | SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES | KYORIN SEIYAKU KK (JP) | 2005-05-25 | — | — | EP | claimed |
| EP-1213287-B1 | SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES | KYORIN SEIYAKU KK (JP) | 2005-05-25 | — | — | EP | claimed |
| EP-1207156-B1 | SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES | KYORIN SEIYAKU KK (JP) | 2005-05-18 | — | — | EP | claimed |
| US-6780431-B1 | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONISTS; METABOLIC DISEASES SUCH AS DIABETES AND HYPERLIPIDEMIA | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2004-08-24 | — | — | US | claimed |
| US-6734199-B1 | SUCH AS N-((4-BENZYLOXYPHENYL)-METHYL)-5-((2,4-DIOXOTHIAZOLIDIN-5-YL)METHYL)-2 -METHOXYBENZAMIDE, HYPOGLYCEMIC AND LIPID LOWERING EFFECT VIA PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2004-05-11 | — | — | US | claimed |
| US-6730687-B1 | THERAPY OF METABOLIC DISEASES SUCH AS DIABETES AND HYPERLIPIDEMIA AS AGONISTS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2004-05-04 | — | — | US | claimed |
| US-6552042-B2 | Anticoagulants | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-04-22 | — | — | US | claimed |
| US-6545026-B1 | Increase the transactivation of receptor as a ligand of human peroxisome proliferator-activated receptor and exhibit blood glucose-decreasing action and lipid-decreasing action | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2003-04-08 | — | — | US | claimed |
| EP-1213287-A1 | SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2002-06-12 | — | — | EP | claimed |
| EP-1207157-A1 | SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2002-05-22 | — | — | EP | claimed |
| EP-1207156-A1 | SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2002-05-22 | — | — | EP | claimed |
| EP-1207158-A1 | SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2002-05-22 | — | — | EP | claimed |
| US-20010021775-A1 | Benzimidazolinones, benzoxazolinones, benzopiperazinones, indanones, and derivatives thereof as inhibitors of factor Xa | HAN QI (US) | 2001-09-13 | — | — | US | claimed |
| US-6207697-B1 | AMIDINYL-SUBSTITUTED RINGS; ANTICOAGULANTS; THROMBOEMBOLIC DISORDERS; ANTIISCHEMIC AND ANTIINFLAMMATORY AGENTS; STROKES; SERINE PROTEASE INHIBITORS | DUPONT PHARMACEUTICALS COMPANY | 2001-03-27 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070059260-A1 | Benzyl-1,3-thiazolidine-2,4-dione compounds for promoting and/or inducing and/or stimulating the pigmentation of keratin materials and/or for limiting their depigmentation and/or whitening | KRT18, TYR, MITF | GSK3A 937/4885GSK3B 1162/4885ALDH1A1 364/4885 |
| US-20070065472-A1 | Benzyl-1,3-thiazolidine-2,4-dione compounds for stimulating or inducing the growth and/or for reducing the loss of keratin fibers | KRT18, FGF1, BRD7 | GSK3A 1355/4885GSK3B 1672/4885ALDH1A1 837/4885 |
| US-20010021775-A1 | Benzimidazolinones, benzoxazolinones, benzopiperazinones, indanones, and derivatives thereof as inhibitors of factor Xa | F12, F13B, F11 | GSK3A 742/4885GSK3B 638/4885ALDH1A1 1992/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.