Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 4/20 | 0.69 |
| ▸ | PDE4A | P27815 | 2/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.68 |
| ▸ | BLM | P54132 | 1/20 | 0.68 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10513991 | 0.83 | PDE3A (0.64) | PDE3APDE4ACYP3A4HPGDNFKB1 | |
| Olprinone SCHEMBL27661 | 0.82 | PDE3A (1.00) | PDE3APDE4ACYP3A4HPGDNFKB1 | |
| Olprinone SCHEMBL19205852 | 0.82 | PDE3A (1.00) | PDE3APDE4ACYP3A4HPGDNFKB1 | |
| Olprinone SCHEMBL6052374 | 0.81 | HPGD (1.00) | PDE3APDE4ACYP3A4HPGDNFKB1 | |
| Olprinone SCHEMBL563912 | 0.81 | HPGD (1.00) | PDE3APDE4ACYP3A4HPGDNFKB1 | |
| Olprinone SCHEMBL27901698 | 0.81 | PDE3A (0.98) | PDE3APDE4ACYP3A4HPGDNFKB1 | |
| SCHEMBL10512208 | 0.79 | PDE3A (0.61) | PDE3APDE4ACYP3A4HPGDNFKB1 | |
| Olprinone SCHEMBL931814 | 0.78 | PDE3A (0.90) | PDE3APDE4ACYP3A4HPGDNFKB1 | |
| SCHEMBL11235286 | 0.72 | PDE3B (1.00) | PDE3APDE4ACYP3A4HPGDBLM | |
| Olprinone SCHEMBL28068934 | 0.72 | PDE3A (0.77) | PDE3APDE4ACYP3A4HPGDNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4803276-A | CARDIOTONIC AGENTS, VASODILATION | EISAI CO., LTD. (JP) | 1989-02-07 | — | — | US | disclosed |
| US-4791203-A | CARDIOTONIC AGENTS | EISAI CO., LTD. (JP) | 1988-12-13 | — | — | US | disclosed |
| US-4791202-A | CARDIOTONIC AGENTS; CONGESTIVE HEART FAILURE | EISAI CO., LTD. (JP) | 1988-12-13 | — | — | US | disclosed |
| US-4751227-A | 3-cyano-5-(6-imidazo[1,2-a]pyridyl)pyridin-2-ols useful as cardiotonics | EISAI CO., LTD. (JP) | 1988-06-14 | — | — | US | disclosed |
| EP-0199127-A1 | 5-(6-imidazo[1,2-a]pyridyl) pyridine derivative | Eisai Co., Ltd. (JP) | 1986-10-29 | — | — | EP | disclosed |