Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Olprinone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A known ✓ | Q14432 | 7/20 | 0.90 |
| ▸ | PDE4A | P27815 | 2/20 | 0.90 |
| ▸ | HPGD | P15428 | 3/20 | 0.88 |
| ▸ | BLM | P54132 | 2/20 | 0.88 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.88 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.88 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.88 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.88 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.69 |
| ▸ | PDE5A | O76074 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.69 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.69 |
| ▸ | PDE2A | O00408 | 1/20 | 0.57 |
| ▸ | PDE1A | P54750 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Olprinone SCHEMBL27661 | 0.95 | PDE3A (1.00) | PDE3APDE4AHPGDBLMCYP3A4 | |
| Olprinone SCHEMBL19205852 | 0.95 | PDE3A (1.00) | PDE3APDE4AHPGDBLMCYP3A4 | |
| Olprinone SCHEMBL27901698 | 0.94 | PDE3A (0.98) | PDE3APDE4AHPGDBLMCYP3A4 | |
| Olprinone SCHEMBL6052374 | 0.94 | HPGD (1.00) | PDE3APDE4AHPGDBLMCYP3A4 | |
| Olprinone SCHEMBL563912 | 0.94 | HPGD (1.00) | PDE3APDE4AHPGDBLMCYP3A4 | |
| Olprinone SCHEMBL28068934 | 0.83 | PDE3A (0.77) | PDE3APDE4AHPGDBLMCYP3A4 | |
| Milrinone SCHEMBL9301167 | 0.83 | PDE3A (1.00) | PDE3APDE4AHPGDBLMCYP3A4 | |
| Milrinone SCHEMBL9247989 | 0.83 | PDE3A (1.00) | PDE3APDE4AHPGDBLMCYP3A4 | |
| Milrinone SCHEMBL36947 | 0.83 | PDE3A (1.00) | PDE3APDE4AHPGDBLMCYP3A4 | |
| Milrinone SCHEMBL9309054 | 0.83 | PDE3A (1.00) | PDE3APDE4AHPGDBLMCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002070-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING IRON OVERLOAD DISORDERS OR DISEASES ON WHICH THE REDUCTION IN IRON CONCENTRATION IS EFFECTIVE, WHICH COMPRISES GDF7/BMP12 PROTEIN | 協和発酵キリン株式会社 (JP) | 2011-01-06 | — | — | WO | disclosed |