Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10575027 | 0.90 | SLC2A1 (0.60) | NPC1SMN1; SMN2RAB9AALDH1A1PKM | |
| SCHEMBL10574973 | 0.83 | PKN1 (0.52) | NPC1RAB9AALDH1A1KDM4EHPGD | |
| SCHEMBL5679609 | 0.83 | NPC1 (0.59) | NPC1SMN1; SMN2RAB9AALDH1A1PKM | |
| SCHEMBL21705378 | 0.82 | HDAC6 (0.61) | NPC1SMN1; SMN2RAB9AALDH1A1PKM | |
| SCHEMBL31027945 | 0.82 | HDAC6 (0.61) | NPC1SMN1; SMN2RAB9AALDH1A1PKM | |
| SCHEMBL10573902 | 0.81 | NPC1 (0.54) | NPC1SMN1; SMN2RAB9AALDH1A1PKM | |
| SCHEMBL419326 | 0.81 | NPC1 (0.71) | NPC1SMN1; SMN2RAB9AALDH1A1PKM | |
| SCHEMBL10574944 | 0.81 | CHEK2 (0.56) | NPC1SMN1; SMN2RAB9AALDH1A1PKM | |
| SCHEMBL14669434 | 0.79 | NPC1 (0.57) | NPC1SMN1; SMN2RAB9AALDH1A1PKM | |
| SCHEMBL10574269 | 0.78 | NPC1 (0.48) | NPC1SMN1; SMN2RAB9AALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |