Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | PKM | P14618 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | NPBWR1 | P48145 | 8/20 | 0.58 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.54 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17393727 | 0.88 | NR1H4 (0.61) | NPC1ALDH1A1SMN1; SMN2PKMKDM4E | |
| SCHEMBL15245140 | 0.86 | DGAT1 (0.67) | NPBWR1DGAT1KCNH2TRPV1SOAT1 | |
| SCHEMBL15245236 | 0.85 | TRPV1 (0.60) | NPBWR1DGAT1KCNH2TRPV1SOAT1 | |
| SCHEMBL17255241 | 0.85 | RAB9A (0.52) | NPC1ALDH1A1SMN1; SMN2PKMKDM4E | |
| SCHEMBL15245163 | 0.85 | NPBWR1 (0.54) | NPC1ALDH1A1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL31027889 | 0.85 | HDAC6 (0.64) | NPBWR1DGAT1KCNH2TRPV1SOAT1 | |
| SCHEMBL21705325 | 0.85 | HDAC6 (0.64) | NPBWR1DGAT1KCNH2TRPV1SOAT1 | |
| SCHEMBL419326 | 0.84 | NPC1 (0.71) | NPC1ALDH1A1SMN1; SMN2PKMKDM4E | |
| SCHEMBL11903647 | 0.84 | TRPV1 (0.62) | NPC1ALDH1A1SMN1; SMN2PKMKDM4E | |
| SCHEMBL15231318 | 0.84 | NPBWR1 (0.59) | NPBWR1DGAT1KCNH2SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620413-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004098494-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2004-11-18 | — | — | WO | disclosed |