Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | TACR3 | P29371 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MGLL | Q99685 | 1/20 | 0.53 |
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23682656 | 0.83 | TACR3 (0.83) | KDM4ETACR3ALDH1A1TP53HSD17B10 | |
| SCHEMBL10572949 | 0.82 | ALDH1A1 (0.56) | KDM4EALDH1A1RAB9APOLBROCK1 | |
| SCHEMBL27648403 | 0.80 | KDM4E (0.59) | KDM4ESMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL10576036 | 0.79 | ALDH1A1 (0.81) | KDM4ESMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL17937010 | 0.78 | ALDH1A1 (0.59) | KDM4ESMN1; SMN2ALDH1A1HSD17B10KMT2A | |
| SCHEMBL2603243 | 0.78 | KDM4E (0.50) | KDM4ESMN1; SMN2ALDH1A1POLB | |
| SCHEMBL16002869 | 0.78 | EPHX2 (0.56) | KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL10574538 | 0.78 | ALDH1A1 (0.58) | KDM4ESMN1; SMN2ALDH1A1RAB9AMEN1 | |
| SCHEMBL6037163 | 0.77 | KDM4E (0.70) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL19658396 | 0.77 | EPHX2 (0.56) | KDM4ESMN1; SMN2ALDH1A1HSD17B10FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4877795-A | 4H-quinolizin-4-one compounds useful for the treatment of allergic bronchial asthma, allergic rhinitis atropic dermatitis and the like | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-10-31 | — | — | US | disclosed |
| EP-0277755-A1 | 4H-quinolizin-4-one compounds exhibiting therapeutic activities | Kissei Pharmaceutical Co. Ltd. (JP) | 1988-08-10 | — | — | EP | disclosed |