Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27648403 | 0.88 | KDM4E (0.59) | EPHX2KDM4ESMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL19658750 | 0.86 | EPHX2 (0.54) | EPHX2KDM4ESMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL19652191 | 0.86 | EPHX2 (0.52) | EPHX2KDM4ESMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL19226493 | 0.83 | KDM4E (0.57) | EPHX2KDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL13873113 | 0.83 | EPHX2 (0.57) | EPHX2KDM4ESMN1; SMN2ALDH1A1FAAH | |
| SCHEMBL29566603 | 0.83 | GPR119 (0.61) | EPHX2KDM4ESMN1; SMN2FAAH | |
| SCHEMBL1088570 | 0.83 | GPR119 (0.61) | EPHX2KDM4ESMN1; SMN2FAAH | |
| SCHEMBL8302404 | 0.81 | KDM4E (0.50) | EPHX2KDM4ESMN1; SMN2KCNH2HRH3 | |
| SCHEMBL27748308 | 0.81 | KDM4E (0.54) | EPHX2KDM4ESMN1; SMN2L3MBTL1HRH3 | |
| SCHEMBL17888371 | 0.81 | SLC6A7 (0.55) | EPHX2KDM4ESMN1; SMN2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BRD4, BRDT, BRD3 | EPHX2 2560/4885KDM4E 320/4885SMN1; SMN2 1221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.