Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 5/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10578437 | 0.92 | HDAC6 (0.35) | NPBWR1HDAC6TRPV1AAK1NPC1 | |
| SCHEMBL10574710 | 0.88 | NPC1 (0.51) | NPBWR1HDAC6TRPV1DGAT1KCNH2 | |
| SCHEMBL10578703 | 0.86 | DGAT1 (0.55) | NPBWR1DGAT1KCNH2NPC1RAB9A | |
| SCHEMBL10571906 | 0.85 | DGAT1 (0.42) | NPBWR1HDAC6TRPV1DGAT1KCNH2 | |
| SCHEMBL10576865 | 0.85 | HDAC6 (0.43) | NPBWR1HDAC6TRPV1DGAT1KCNH2 | |
| SCHEMBL10578455 | 0.84 | NPBWR1 (0.56) | NPBWR1HDAC6TRPV1DGAT1KCNH2 | |
| SCHEMBL10579971 | 0.84 | NPC1 (0.49) | NPBWR1HDAC6TRPV1DGAT1KCNH2 | |
| SCHEMBL10574680 | 0.84 | NPBWR1 (0.59) | NPBWR1HDAC6TRPV1DGAT1KCNH2 | |
| SCHEMBL10574922 | 0.83 | HDAC6 (0.43) | NPBWR1HDAC6TRPV1DGAT1KCNH2 | |
| SCHEMBL10575422 | 0.83 | HRH4 (0.41) | NPBWR1HDAC6TRPV1DGAT1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |