Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | ANPEP | P15144 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10580655 | 0.92 | POLB (0.59) | POLBGAATHRBROCK2S1PR1 | |
| SCHEMBL28699163 | 0.75 | S1PR1 (0.77) | POLBGAAS1PR1S1PR3ALDH1A1 | |
| SCHEMBL4247770 | 0.75 | POLB (0.66) | POLBGAAS1PR1S1PR3ALDH1A1 | |
| SCHEMBL31606452 | 0.74 | FDPS (0.44) | POLBGAAALDH1A1NPC1RAB9A | |
| SCHEMBL3781893 | 0.73 | HRH1 (0.59) | CYP2D6CYP2C19 | |
| SCHEMBL24932269 | 0.73 | POLB (1.00) | POLBGAAS1PR1S1PR3ALDH1A1 | |
| SCHEMBL24932435 | 0.73 | POLB (1.00) | POLBGAAS1PR1S1PR3ALDH1A1 | |
| SCHEMBL4618907 | 0.71 | GAA (0.63) | POLBGAAALDH1A1NPC1RAB9A | |
| SCHEMBL13149787 | 0.70 | GAA (0.73) | POLBGAAALDH1A1NPC1RAB9A | |
| SCHEMBL7873450 | 0.70 | ANPEP (0.61) | POLBGAAS1PR1S1PR3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4847301-A | Methods of use of α-(aminoalkyl)-arylacetic acid derivatives | PENNWALT CORPORATION (US) | 1989-07-11 | — | — | US | disclosed |
| US-4783537-A | CARDIOVASCULAR DISORDERS | PENNWALT CORPORATION (US) | 1988-11-08 | — | — | US | disclosed |
| EP-0222099-A2 | Alpha-(Aminoalkyl)-Arylacetic Acid Derivatives | FISONS CORPORATION (a Massachusetts corporation) (US) | 1987-05-20 | — | — | EP | disclosed |