Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 7/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.48 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.47 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9590000 | 0.86 | ANPEP (0.58) | ANPEPALDH1A1GAAPOLBRAB9A | |
| SCHEMBL9602121 | 0.86 | ANPEP (0.58) | ANPEPALDH1A1GAAPOLBRAB9A | |
| SCHEMBL7418597 | 0.83 | POLB (0.55) | ANPEPALDH1A1GAAPOLBRAB9A | |
| SCHEMBL26741187 | 0.80 | ALDH1A1 (0.60) | ANPEPALDH1A1GAAPOLBRAB9A | |
| SCHEMBL26741146 | 0.80 | ALDH1A1 (0.60) | ANPEPALDH1A1GAAPOLBRAB9A | |
| SCHEMBL7876499 | 0.80 | ANPEP (0.52) | ANPEPALDH1A1GAAPOLBRAB9A | |
| SCHEMBL15143051 | 0.79 | LTA4H (0.56) | ALDH1A1RAB9ANPC1LNPEPERAP2 | |
| SCHEMBL4952247 | 0.79 | KDM4E (0.51) | ANPEPALDH1A1GAAPOLBRAB9A | |
| SCHEMBL7776518 | 0.78 | GAA (0.83) | ALDH1A1GAAPOLBRAB9ANPC1 | |
| SCHEMBL7873432 | 0.77 | TSHR (0.51) | ANPEPALDH1A1GAAPOLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |