Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Midesteine SCHEMBL724755 | 0.80 | ELANE (1.00) | ELANEMAPK1ALDH1A1CYP1A2KMT2A | |
| SCHEMBL10589615 | 0.79 | MAPT (0.41) | ELANEALDH1A1KMT2AMEN1CTSK | |
| SCHEMBL9356448 | 0.77 | ELANE (0.81) | ELANEMAPK1ALDH1A1CYP1A2KMT2A | |
| SCHEMBL9630054 | 0.76 | MAPT (0.52) | ALDH1A1KMT2AMAPTADAM17ATM | |
| SCHEMBL9630045 | 0.76 | MAPT (0.52) | ALDH1A1KMT2AMAPTADAM17ATM | |
| SCHEMBL10587465 | 0.74 | CYP1A2 (0.58) | ELANEALDH1A1CYP1A2KMT2AMEN1 | |
| SCHEMBL10587067 | 0.72 | KMT2A (0.40) | ELANEMAPK1ALDH1A1KMT2AMEN1 | |
| SCHEMBL11113900 | 0.72 | MAPK1 (0.78) | ELANEMAPK1ALDH1A1CYP1A2KMT2A | |
| SCHEMBL10589133 | 0.72 | ELANE (0.57) | ELANEMAPK1ALDH1A1POLB | |
| SCHEMBL21007472 | 0.69 | CYP1A2 (0.73) | ELANEALDH1A1CYP1A2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0336326-A2 | 3-Aminodihydrothiophene-2-one peptide derivatives, processes for the preparation and therapeutic use | POLI INDUSTRIA CHIMICA S.p.A. (IT) | 1989-10-11 | — | — | EP | claimed |
| EP-0336326-A2 | 3-Aminodihydrothiophene-2-one peptide derivatives, processes for the preparation and therapeutic use | POLI INDUSTRIA CHIMICA S.p.A. (IT) | 1989-10-11 | — | — | EP | disclosed |