Desoxycorticosterone

SCHEMBL10593143

CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C.C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)CO

nearest known ligand 0.92

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PGR

The experimentally established mechanism targets of Desoxycorticosterone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	PGR known ✓	P06401	2/20	0.86

▸	LMNA	P02545	8/20	0.92

▸	SMN1; SMN2	Q16637	7/20	0.92

▸	ALDH1A1	P00352	6/20	0.92

▸	CYP3A4	P08684	6/20	0.92

▸	MAPT	P10636	6/20	0.92

▸	MAPK1	P28482	5/20	0.92

▸	SERPINA6	P08185	4/20	0.92

▸	SHBG	P04278	3/20	0.92

▸	HSD17B10	Q99714	3/20	0.92

▸	ABCB11	O95342	2/20	0.92

▸	HIF1A	Q16665	4/20	0.86

▸	CYP2C9	P11712	3/20	0.86

▸	TSHR	P16473	3/20	0.86

▸	NR3C2	P08235	3/20	0.86

▸	MEN1	O00255	2/20	0.86

▸	KMT2A	Q03164	2/20	0.86

▸	NR1I2	O75469	2/20	0.86

▸	NR3C1	P04150	2/20	0.86

▸	SLC22A2	O15244	2/20	0.86

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Desoxycorticosterone SCHEMBL21243062	0.96	LMNA (1.00)	LMNASMN1; SMN2ALDH1A1CYP3A4MAPT
Desoxycorticosterone SCHEMBL15763287	0.96	LMNA (1.00)	LMNASMN1; SMN2ALDH1A1CYP3A4MAPT
Desoxycorticosterone SCHEMBL25773308	0.96	LMNA (1.00)	LMNASMN1; SMN2ALDH1A1CYP3A4MAPT
Desoxycorticosterone SCHEMBL13752803	0.96	LMNA (1.00)	LMNASMN1; SMN2ALDH1A1CYP3A4MAPT
Desoxycorticosterone SCHEMBL18891475	0.96	LMNA (1.00)	LMNASMN1; SMN2ALDH1A1CYP3A4MAPT
Desoxycorticosterone SCHEMBL4065	0.96	LMNA (1.00)	LMNASMN1; SMN2ALDH1A1CYP3A4MAPT
Desoxycorticosterone SCHEMBL4066	0.96	LMNA (1.00)	LMNASMN1; SMN2ALDH1A1CYP3A4MAPT
Desoxycorticosterone SCHEMBL28269906	0.96	LMNA (1.00)	LMNASMN1; SMN2ALDH1A1CYP3A4MAPT
Desoxycorticosterone SCHEMBL9504254	0.95	LMNA (0.94)	LMNASMN1; SMN2ALDH1A1CYP3A4MAPT
Progesterone SCHEMBL7714079	0.93	LMNA (0.88)	LMNASMN1; SMN2ALDH1A1CYP3A4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-4870005-A	MEDICAL DIAGNOSIS, IMMUNOASSAY	FUJI PHOTO FILM CO., LTD. (JP)	1989-09-26	—	—	US	disclosed