Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Progesterone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR known ✓ | P06401 | 4/20 | 0.88 |
| ▸ | LMNA | P02545 | 8/20 | 0.88 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.88 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.88 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.88 |
| ▸ | MAPT | P10636 | 5/20 | 0.88 |
| ▸ | SERPINA6 | P08185 | 5/20 | 0.88 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.88 |
| ▸ | TSHR | P16473 | 4/20 | 0.88 |
| ▸ | SHBG | P04278 | 4/20 | 0.88 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.88 |
| ▸ | AR | P10275 | 3/20 | 0.88 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.88 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.88 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.88 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.88 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.88 |
| ▸ | MEN1 | O00255 | 2/20 | 0.88 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.88 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Progesterone SCHEMBL10791303 | 0.95 | CYP3A4 (0.98) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| Progesterone SCHEMBL28255054 | 0.94 | LMNA (0.88) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| Progesterone SCHEMBL14629858 | 0.94 | LMNA (0.91) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| Progesterone SCHEMBL220821 | 0.94 | CYP3A4 (0.95) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| Progesterone SCHEMBL23568915 | 0.94 | CYP3A4 (1.00) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| Progesterone SCHEMBL13259536 | 0.94 | CYP3A4 (1.00) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| Progesterone SCHEMBL7671 | 0.94 | CYP3A4 (1.00) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| Progesterone SCHEMBL17750737 | 0.94 | CYP3A4 (1.00) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| Progesterone SCHEMBL15224316 | 0.94 | CYP3A4 (1.00) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| Progesterone SCHEMBL8430168 | 0.94 | CYP3A4 (1.00) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114057821-B | Preparation method of medroxyprogesterone acetate for perimenopausal syndrome | 黑龙江中医药大学 | 2022-12-09 | — | — | CN | claimed |
| CN-114057821-A | Preparation method of medroxyprogesterone acetate for perimenopausal syndrome | 黑龙江中医药大学 | 2022-02-18 | — | — | CN | claimed |
| CN-106977569-B | Preparation method of 6-methylene-17 α -hydroxyprogesterone acetate | 杭州弘任医药科技有限公司 | 2020-06-23 | — | — | CN | claimed |
| CN-108912193-B | Production process and production device of medroxyprogesterone acetate | 岳阳环宇药业有限公司 | 2020-05-19 | — | — | CN | claimed |
| CN-110618225-A | Method for constructing database to detect hormone | 吉林出入境检验检疫局检验检疫技术中心 | 2019-12-27 | — | — | CN | claimed |
| CN-110590890-A | Preparation method of 17 alpha-acetoxyl group-6-methylene pregn-4-ene-3, 20-diketone | 台州仙琚药业有限公司 | 2019-12-20 | — | — | CN | claimed |
| EP-3614113-B1 | TEMPERATURE DETECTING MATERIAL AND PRODUCT CONTROL METHOD | HITACHI INDUSTRY EQUIPMENT SYSTEMS CO LTD (JP) | 2024-07-17 | — | — | EP | disclosed |
| CN-114057821-B | Preparation method of medroxyprogesterone acetate for perimenopausal syndrome | 黑龙江中医药大学 | 2022-12-09 | — | — | CN | disclosed |
| CN-107638562-B | Rapid establishment and/or termination of substantial steady-state drug delivery | 精达制药公司 | 2022-12-02 | — | — | CN | disclosed |
| CN-110114647-B | Temperature detection material, manufacturing method thereof and application of temperature detection material | 株式会社日立产机系统 | 2022-04-22 | — | — | CN | disclosed |
| CN-114057821-A | Preparation method of medroxyprogesterone acetate for perimenopausal syndrome | 黑龙江中医药大学 | 2022-02-18 | — | — | CN | disclosed |
| CN-108367012-B | Treatment of autoimmune and autoinflammatory diseases | 深圳埃格林医药有限公司 | 2021-12-24 | — | — | CN | disclosed |
| CN-111542736-A | Temperature detection material and system for estimating temperature deviation time using same | 株式会社日立产机系统 | 2020-08-14 | — | — | CN | disclosed |
| EP-0674528-A1 | CYCLODEXTRIN AND POLYMER BASED DRUG DELIVERY SYSTEM | INSITE VISION INCORPORATED (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014416-A1 | BIOERODIBLE CONTROLLED DELIVERY SYSTEM | INSITE VISION INCORPORATED (US) | 1994-07-07 | — | — | WO | disclosed |
| WO-1994014417-A1 | PLASTICIZED BIOERODIBLE CONTROLLED DELIVERY SYSTEM | INSITE VISION INCORPORATED (US) | 1994-07-07 | — | — | WO | disclosed |
| WO-1994012217-A1 | CYCLODEXTRIN AND POLYMER BASED DRUG DELIVERY SYSTEM | INSITE VISION INCORPORATED (US) | 1994-06-09 | — | — | WO | disclosed |
| US-4957494-A | Multi-layer delivery system | ALZA CORPORATION (US) | 1990-09-18 | — | — | US | disclosed |
| US-4874388-A | Multi-layer delivery system | ALZA CORPORATION (US) | 1989-10-17 | — | — | US | disclosed |
| US-4684524-A | Rate controlled dispenser for administering beneficial agent | ALZA CORPORATION (US) | 1987-08-04 | — | — | US | disclosed |