SCHEMBL1059455

SCHEMBL1059455

[O]C1CNCCO1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27521637 1.00
SCHEMBL27521815 1.00
SCHEMBL11405642 0.71 DRD2 (0.34)
SCHEMBL7400413 0.70
SCHEMBL337118 0.70
SCHEMBL8164385 0.70
Hydrochloric Acid SCHEMBL16094440 0.69 SSTR4 (0.47)
Hydrochloric Acid SCHEMBL16095751 0.69 SSTR4 (0.47)
Hydrochloric Acid SCHEMBL1609138 0.69 SSTR4 (0.47)
SCHEMBL8722591 0.69 SSTR4 (0.37)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1092 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1730152-B1 TETRAHYDROQUINOLINE DERIVATIVES AND A PROCESS FOR PREPARING THE SAME MITSUBISHI TANABE PHARMA CORP (JP) 2012-05-02 EP claimed
WO-2012048411-A1 PLK-4 INHIBITORS AND METHOD OF TREATING CANCER WITH SAME UNIVERSITY HEALTH NETWORK (CA) 2012-04-19 WO claimed
US-20110039828-A1 TETRAHYDROQUINOLINE DERIVATIVES AND A PROCESS FOR PREPARING THE SAME MITSUBISHI TANABE PHARMA CORPORATION (JP) 2011-02-17 US claimed
EP-2155202-A2 3,6-DISUBSTITUTED-IMIDAZO[1,2-B]PYRIDAZINES AND 3,5-DISUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINES AS PHOSPHATIDYLINOSITOL-3-KINASE INHIBITORS Novartis Ag (CH) 2010-02-24 EP claimed
US-20090023728-A1 1,2,3,4-Tetrahydroisoquinoline Derivatives, Preparations Thereof and Uses Thereof ASTRAZENECA AB (SE) 2009-01-22 US claimed
WO-2008138889-A2 3, 6-DISUBSTITUTED-IMIDAZO [1, 2-B] PYRIDAZINES AND 3, 5-DISUBSTITUTED PYRAZOLO[1, 5-A] PYRIMIDINES AS PHOSPHATIDYLINOSITOL-3-KINASE INHIBITORS NOVARTIS AG (CH) 2008-11-20 WO claimed
US-20070082896-A1 Tetrahydroquinoline derivatives and a process for preparing the same TANABE SEIYAKU CO., LTD. 2007-04-12 US claimed
US-20070032485-A1 Tetrahydronaphthyridine derivatives and a process for preparing the same TANABE SEIYAKU CO., LTD. 2007-02-08 US claimed
EP-1730152-A2 TETRAHYDROQUINOLINE DERIVATIVES AND A PROCESS FOR PREPARING THE SAME TANABE SEIYAKU CO., LTD. (JP) 2006-12-13 EP claimed
CN-1285580-C Pyrimidine compounds ASTRAZENECA UK LTD (SE) 2006-11-22 CN claimed
EP-1699779-A1 1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF AstraZeneca AB (SE) 2006-09-13 EP claimed
CN-1256326-C Novel 4- (oxoxyphenyl) -3-oxopiperidines for the treatment of cardiac and renal insufficiency HOFFMANN LA ROCHE (CH) 2006-05-17 CN claimed
WO-2005095409-A2 TETRAHYDROQUINOLINE DERIVATIVES AND A PROCESS FOR PREPARING THE SAME TANABE SEIYAKU CO., LTD. (JP) 2005-10-13 WO claimed
WO-2005061484-A1 1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF ASTRAZENECA AB (SE) 2005-07-07 WO claimed
CN-1335838-A Pyrimidine compounds ASTRAZENECA UK LTD (SE) 2002-02-13 CN claimed
EP-0161867-A2 5,6,7,8-Tetrahydroquinolines and 5,6-dihydropyrindines and their therapeutic use THE UPJOHN COMPANY (US) 1985-11-21 EP claimed
EP-3632441-B1 METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND DAY ONE BIOPHARMACEUTICALS INC (US) 2024-07-17 EP disclosed
US-12036209-B2 Compounds and methods for the targeted degradation of Interleukin-1 receptor-associated kinase 4 polypeptides ARVINAS OPERATIONS, INC. (US) 2024-07-16 US disclosed
EP-0161867-A3 5,6,7,8-TETRAHYDROQUINOLINES AND 5,6-DIHYDROPYRINDINES AND THEIR THERAPEUTIC USE THE UPJOHN COMPANY (US) 1987-04-15 EP disclosed
EP-0161867-A2 5,6,7,8-Tetrahydroquinolines and 5,6-dihydropyrindines and their therapeutic use THE UPJOHN COMPANY (US) 1985-11-21 EP disclosed