Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 11/20 | 0.61 |
| ▸ | ADRB1 | P08588 | 9/20 | 0.61 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.61 |
| ▸ | HTR1A | P08908 | 3/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.61 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | CASR | P41180 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10592480 | 0.84 | ABCB1 (0.42) | ADRB2ADRB1ADRB3HTR1ASLC6A4 | |
| SCHEMBL10594588 | 0.83 | CYP2D6 (0.45) | ADRB2ADRB1ADRB3CASRCYP2D6 | |
| SCHEMBL10593574 | 0.82 | ABCB1 (0.42) | ADRB2ADRB1ADRB3HTR1ASLC6A4 | |
| SCHEMBL10505401 | 0.82 | ADRB2 (0.40) | ADRB2ADRB1ADRB3CASR | |
| SCHEMBL10592061 | 0.82 | CASR (0.50) | ADRB2ADRB1ADRB3CASR | |
| SCHEMBL10592879 | 0.81 | HTR1A (0.61) | ADRB2ADRB1ADRB3HTR1ASLC6A4 | |
| SCHEMBL10504355 | 0.81 | ADRB2 (0.37) | ADRB2ADRB1ADRB3HTR1ASLC6A4 | |
| SCHEMBL10595545 | 0.81 | HTR1A (0.42) | ADRB2ADRB1ADRB3HTR1ASLC6A4 | |
| SCHEMBL10503937 | 0.80 | HTR1A (0.56) | ADRB2ADRB1ADRB3HTR1ASLC6A4 | |
| SCHEMBL10504192 | 0.80 | ADRB2 (0.37) | ADRB2ADRB1ADRB3HTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863949-A | CARDIOVASCULAR DISORDER TREATMENT | BOEHRINGER MANNHEIM GMBH (DE) | 1989-09-05 | — | — | US | disclosed |
| EP-0200915-A1 | Aminopropanol derivatives, process for their preparation, their use and medicines containing them | Roche Diagnostics GmbH (DE) | 1986-11-12 | — | — | EP | disclosed |