Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 9/20 | 0.56 |
| ▸ | NR3C1 | P04150 | 8/20 | 0.56 |
| ▸ | AR | P10275 | 6/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10597057 | 1.00 | PGR (0.56) | PGRNR3C1ARCYP3A4ABCB11 | |
| SCHEMBL10598724 | 0.90 | PGR (0.70) | PGRNR3C1ARCYP3A4ABCB11 | |
| SCHEMBL10940741 | 0.90 | PGR (0.47) | PGRNR3C1ARCYP3A4ABCB11 | |
| SCHEMBL10945949 | 0.85 | NR3C1 (0.54) | PGRNR3C1ARCYP3A4ABCB11 | |
| SCHEMBL10945872 | 0.82 | PGR (0.55) | PGRNR3C1ARCYP3A4ABCB11 | |
| SCHEMBL10944309 | 0.78 | NR3C1 (0.66) | PGRNR3C1ARCYP3A4ABCB11 | |
| SCHEMBL10821033 | 0.77 | PGR (0.79) | PGRNR3C1ARCYP3A4ABCB11 | |
| SCHEMBL10596154 | 0.76 | PGR (0.54) | PGRNR3C1ARCYP3A4ABCB11 | |
| SCHEMBL10820961 | 0.75 | PGR (0.79) | PGRNR3C1ARCYP3A4ABCB11 | |
| Norethindrone Acetate SCHEMBL37530 | 0.72 | CYP3A4 (1.00) | PGRNR3C1ARCYP3A4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4557867-A | CONTRACEPTIVES | THE UPJOHN COMPANY (US) | 1985-12-10 | — | — | US | claimed |
| EP-0145493-B1 | 11-DIFLUOROMETHYL AND 11-FLUOROMETHYLENE STEROIDS | THE UPJOHN COMPANY (US) | 1989-03-08 | — | — | EP | disclosed |
| US-4557867-A | CONTRACEPTIVES | THE UPJOHN COMPANY (US) | 1985-12-10 | — | — | US | disclosed |
| EP-0145493-A2 | 11-Difluoromethyl and 11-fluoromethylene steroids | THE UPJOHN COMPANY (US) | 1985-06-19 | — | — | EP | disclosed |