Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCN4 | Q9Y3Q4 | 5/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10601193 | 0.91 | HCN4 (0.67) | HCN4MAPTCYP3A4ALOX15CHRM2 | |
| SCHEMBL10601090 | 0.86 | HCN4 (0.58) | HCN4MAPTCYP3A4ALOX15CHRM2 | |
| SCHEMBL10598399 | 0.81 | HCN4 (0.92) | HCN4MAPTCYP3A4ALOX15CHRM2 | |
| Zatebradine SCHEMBL4242335 | 0.81 | HCN4 (1.00) | HCN4MAPTCYP3A4ALOX15CHRM2 | |
| Zatebradine SCHEMBL29977754 | 0.81 | HCN4 (1.00) | HCN4MAPTCYP3A4ALOX15CHRM2 | |
| Zatebradine SCHEMBL295751 | 0.81 | HCN4 (1.00) | HCN4MAPTCYP3A4ALOX15CHRM2 | |
| SCHEMBL10598410 | 0.81 | HCN4 (0.55) | HCN4MAPTCYP3A4ALOX15CHRM2 | |
| Zatebradine SCHEMBL10978655 | 0.81 | CYP3A4 (1.00) | HCN4MAPTCYP3A4ALOX15CHRM2 | |
| SCHEMBL10847748 | 0.81 | HCN4 (0.73) | HCN4MAPTCYP3A4ALOX15CHRM2 | |
| Zatebradine SCHEMBL1588590 | 0.81 | CYP3A4 (1.00) | HCN4MAPTCYP3A4ALOX15CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0109636-B1 | BENZAZEPINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOUNDS | Dr. Karl Thomae GmbH (DE) | 1989-01-18 | — | — | EP | disclosed |
| US-4490369-A | HYPOTENSIVE, BRRADYCARDIAL | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-12-25 | — | — | US | disclosed |
| EP-0109636-A2 | Benzazepine derivatives, process for their preparation and their use as pharmaceutical compounds | Dr. Karl Thomae GmbH (DE) | 1984-05-30 | — | — | EP | disclosed |