Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | HMGCR | P04035 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12683752 | 0.90 | ALOX5 (0.41) | ALOX5PTGS2CA12CA1CA2 | |
| SCHEMBL28270122 | 0.90 | CA12 (0.40) | ALOX5PTGS2CA12CA1CA2 | |
| SCHEMBL16959188 | 0.87 | SCN8A (0.39) | ALOX5PTGS2CA12CA1CA2 | |
| SCHEMBL7281853 | 0.87 | CA12 (0.55) | ALOX5PTGS2CA12CA1CA2 | |
| SCHEMBL16829571 | 0.86 | ALOX5 (0.53) | ALOX5PTGS2CA12CA1CA2 | |
| SCHEMBL16959184 | 0.86 | ALOX5 (0.38) | ALOX5PTGS2CA12CA1CA2 | |
| SCHEMBL11206775 | 0.86 | CA12 (0.40) | ALOX5PTGS2CA12CA1CA2 | |
| SCHEMBL796853 | 0.86 | HMGCR (0.47) | ALOX5PTGS2CA12CA1CA2 | |
| SCHEMBL10976468 | 0.83 | GABRA1 (0.37) | ALOX5PTGS2HMGCRELANE | |
| SCHEMBL16957848 | 0.82 | ALOX5 (0.39) | ALOX5PTGS2CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0173279-B1 | 2-(3,5-DIALKYL-4-HYDROXYPHENYL)INDOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1989-08-23 | — | — | EP | disclosed |
| US-4695581-A | LIPOXYGENASE INHIBITOR | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1987-09-22 | — | — | US | disclosed |
| EP-0173279-A1 | 2-(3,5-Dialkyl-4-hydroxyphenyl)indole derivatives | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1986-03-05 | — | — | EP | disclosed |