SCHEMBL10600401

SCHEMBL10600401

Fc1cnc(C(F)(F)F)nc1

nearest known ligand 0.32

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TRPV4 Q9HBA0 1/20 0.32
APLNR P35414 1/20 0.31
P2RX7 Q99572 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25011721 0.78
SCHEMBL1169515 0.77 HTT (0.35) TRPV4
SCHEMBL20003501 0.74 TRPV4 (0.52) TRPV4
SCHEMBL254676 0.74 APLNR (0.39) TRPV4APLNR
SCHEMBL156478 0.74 HTT (0.39) TRPV4P2RX7
SCHEMBL17619921 0.74 TRPV4 (0.31) TRPV4
SCHEMBL14865436 0.74 TRPV4 (0.31) TRPV4
SCHEMBL10105664 0.74 CNR1 (0.31) APLNR
SCHEMBL876534 0.74 DEGS1 (0.34) TRPV4
SCHEMBL10775633 0.74 TRPV4 (0.31) TRPV4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9375002-B2 5-aminopyrimidine derivatives and use thereof for combating undesired plant growth BAYER INTELLECTUAL PROPERTY GMBH (DE) 2016-06-28 US disclosed
EP-2831050-B1 5-AMINO PYRIMIDINE DERIVATIVES AND USE THEREOF FOR COMBATING UNDESIRED PLANT GROWTH BAYER IP GMBH (DE) 2016-03-23 EP disclosed
US-20150094205-A1 5-AMINOPYRIMIDINE DERIVATIVES AND USE THEREOF FOR COMBATING UNDESIRED PLANT GROWTH BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-04-02 US disclosed
EP-2831050-A1 5-AMINOPYRIMIDINE DERIVATIVES AND USE THEREOF FOR COMBATING UNDESIRED PLANT GROWTH Bayer Intellectual Property GmbH (DE) 2015-02-04 EP disclosed
WO-2013144187-A1 5-AMINOPYRIMIDINE DERIVATIVES AND USE THEREOF FOR COMBATING UNDESIRED PLANT GROWTH BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-10-03 WO disclosed
EP-0213377-B1 PHOSPHORIC (PHOSPHONIC) ACID ESTERS BAYER AG (DE) 1989-02-15 EP disclosed
US-4774233-A Pesticidally active O-ethyl O-isopropyl O-(2-trifluoromethylpyrimidin-5-yl)-phosphoric acid ester BAYER AKTIENGESELLSCHAFT (DE) 1988-09-27 US disclosed
EP-0236829-A2 2-Trifluoromethyl-5-pyrimidinyloxy-phenyl urea, and process for its preparation BAYER AG (DE) 1987-09-16 EP disclosed
EP-0213377-A1 Phosphoric (phosphonic) acid esters BAYER AG (DE) 1987-03-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150094205-A1 5-AMINOPYRIMIDINE DERIVATIVES AND USE THEREOF FOR COMBATING UNDESIRED PLANT GROWTH PPA1, IMPDH1, NUDT5 TRPV4 4799/4885APLNR 3499/4885P2RX7 1661/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.