Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 15/20 | 0.63 |
| ▸ | CTSD | P07339 | 3/20 | 0.58 |
| ▸ | CTSE | P14091 | 2/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11025160 | 0.93 | REN (0.66) | RENCTSDCTSEBACE1 | |
| SCHEMBL10602239 | 0.92 | REN (0.63) | RENCTSDCTSEBACE1 | |
| SCHEMBL10777493 | 0.90 | REN (0.77) | RENCTSD | |
| SCHEMBL10659161 | 0.88 | REN (0.61) | RENCTSD | |
| SCHEMBL10732229 | 0.88 | REN (0.62) | RENCTSD | |
| SCHEMBL10752754 | 0.88 | REN (0.62) | RENCTSD | |
| SCHEMBL9716785 | 0.87 | REN (0.69) | RENCTSDCTSEBACE1 | |
| SCHEMBL10777425 | 0.87 | REN (0.64) | RENCTSD | |
| SCHEMBL11020013 | 0.87 | REN (0.72) | RENCTSDCTSEBACE1 | |
| SCHEMBL10780890 | 0.86 | REN (0.58) | RENCTSDCTSEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0081783-B2 | RENIN INHIBITORY PEPTIDES HAVING PHE 13 DELETION | MERCK & CO. INC. (US) | 1989-02-08 | — | — | EP | disclosed |
| EP-0081783-B1 | RENIN INHIBITORY PEPTIDES HAVING PHE 13 DELETION | MERCK & CO. INC. (US) | 1985-06-19 | — | — | EP | disclosed |
| US-4479941-A | TREATMENT OF HYPERTENSION AND HYPERALDOSTERONISM | MERCK & CO., INC. (US) | 1984-10-30 | — | — | US | disclosed |
| EP-0081783-A1 | Renin inhibitory peptides having Phe 13 deletion | MERCK & CO. INC. (US) | 1983-06-22 | — | — | EP | disclosed |