SCHEMBL10601098

CC(C)C[C@H](NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)[C](Cc1ccccc1)c1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 5)

	gene	UniProt	supporting neighbours	confidence
▸	REN	P00797	10/20	0.57

▸	CTSD	P07339	1/20	0.54

▸	OPRM1	P35372	1/20	0.47

▸	OPRD1	P41143	1/20	0.47

▸	OPRK1	P41145	1/20	0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL10601418	0.91	REN (0.61)	RENCTSDOPRM1OPRD1OPRK1
SCHEMBL10598680	0.91	REN (0.61)	RENCTSDOPRM1OPRD1OPRK1
SCHEMBL10597941	0.89	REN (0.61)	RENCTSDOPRM1OPRD1OPRK1
SCHEMBL10599812	0.88	REN (0.60)	RENCTSDOPRM1OPRD1OPRK1
SCHEMBL10598784	0.86	REN (0.51)	REN
SCHEMBL10777493	0.86	REN (0.77)	RENCTSD
SCHEMBL10602239	0.85	REN (0.63)	RENCTSD
SCHEMBL11025160	0.85	REN (0.66)	RENCTSD
SCHEMBL29525618	0.84	REN (0.58)	RENOPRM1OPRD1OPRK1
SCHEMBL6516908	0.84	REN (0.58)	RENOPRM1OPRD1OPRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0081783-B2	RENIN INHIBITORY PEPTIDES HAVING PHE 13 DELETION	MERCK & CO. INC. (US)	1989-02-08	—	—	EP	claimed