Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16041473 | 0.79 | ALDH1A1 (0.41) | GABRA1GABRB2ALDH1A1GAAMAPT | |
| SCHEMBL11141768 | 0.77 | GABRA1 (0.39) | GABRA1GABRB2ALDH1A1GAAMAPT | |
| SCHEMBL28899511 | 0.75 | ALDH1A1 (0.43) | GABRA1GABRB2ALDH1A1GAAMAPT | |
| SCHEMBL28899512 | 0.75 | ALDH1A1 (0.43) | GABRA1GABRB2ALDH1A1GAAMAPT | |
| SCHEMBL26145467 | 0.74 | GABRA1 (0.48) | GABRA1GABRB2ALDH1A1TP53ESR1 | |
| SCHEMBL28269522 | 0.74 | GABRA1 (0.41) | GABRA1GABRB2ALDH1A1GAAMAPT | |
| SCHEMBL28899517 | 0.74 | ALDH1A1 (0.40) | GABRA1GABRB2ALDH1A1MAPTTP53 | |
| SCHEMBL16400264 | 0.74 | ALDH1A1 (0.39) | ALDH1A1GAAMAPT | |
| SCHEMBL28269553 | 0.72 | ALDH1A1 (0.41) | GABRA1GABRB2ALDH1A1GAAMAPT | |
| SCHEMBL11138433 | 0.72 | ALDH1A1 (0.41) | GABRA1GABRB2ALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451795-A1 | COMPOSITIONS AND METHODS FOR ENHANCING VIRUS EFFICACY | Ottawa Hospital Research Institute (CA) | 2012-05-16 | — | — | EP | claimed |
| WO-2011003191-A1 | COMPOSITIONS AND METHODS FOR ENHANCING VIRUS EFFICACY | OTTAWA HOSPITAL RESEARCH INSTITUTE (CA) | 2011-01-13 | — | — | WO | claimed |
| CN-105886476-A | Compositions and methods for enhancing virus efficacy | 渥太华医院研究所 | 2016-08-24 | — | — | CN | disclosed |
| EP-2451795-B1 | COMPOSITIONS AND USES FOR ENHANCING VIRUS PRODUCTION | OTTAWA HOSPITAL RES INST (CA) | 2016-07-13 | — | — | EP | disclosed |
| CN-102471300-B | Compositions and methods for enhancing viral potency | OTTAWA HOSPITAL RESEARCH INSTITUTE (CA) | 2016-04-13 | — | — | CN | disclosed |
| EP-2451795-A1 | COMPOSITIONS AND METHODS FOR ENHANCING VIRUS EFFICACY | Ottawa Hospital Research Institute (CA) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011003191-A1 | COMPOSITIONS AND METHODS FOR ENHANCING VIRUS EFFICACY | OTTAWA HOSPITAL RESEARCH INSTITUTE (CA) | 2011-01-13 | — | — | WO | disclosed |