Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.46 |
| ▸ | ACHE | P22303 | 5/20 | 0.43 |
| ▸ | CDC25C | P30307 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5583243 | 0.83 | MAPT (0.60) | MAPTNPSR1PTGS2ACHECDC25C | |
| SCHEMBL5239456 | 0.83 | MAPT (0.42) | MAPTNPSR1PTGS2CDC25CCYP3A4 | |
| SCHEMBL17919915 | 0.80 | MAPT (0.55) | MAPTNPSR1PTGS2ACHECDC25C | |
| SCHEMBL31361989 | 0.78 | MAPT (0.72) | MAPTNPSR1PTGS2ACHEBCHE | |
| SCHEMBL30443281 | 0.77 | MAPT (0.66) | MAPTNPSR1PTGS2ACHEBCHE | |
| SCHEMBL719267 | 0.77 | MAPT (0.66) | MAPTNPSR1PTGS2ACHEBCHE | |
| SCHEMBL6907821 | 0.77 | TSHR (0.60) | ACHECYP3A4TSHRTDP1 | |
| SCHEMBL10600469 | 0.77 | MAPT (0.49) | MAPTNPSR1PTGS2 | |
| SCHEMBL11027809 | 0.76 | MAPT (0.59) | MAPTNPSR1PTGS2ACHECDC25C | |
| SCHEMBL11886403 | 0.75 | MAPT (1.00) | MAPTNPSR1PTGS2ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0133234-B1 | IMIDAZOQUINAZOLIN-2-ONE COMPOUNDS PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS | DAIICHI SEIYAKU CO., LTD. (JP) | 1989-04-12 | — | — | EP | disclosed |
| US-4610987-A | ANTICOAGULANT | DAIICHI SEIYAKU CO., LTD. (JP) | 1986-09-09 | — | — | US | disclosed |
| EP-0133234-A2 | Imidazoquinazolin-2-one compounds process for their production and pharmaceutical compositions containing said compounds | DAIICHI SEIYAKU CO., LTD. (JP) | 1985-02-20 | — | — | EP | disclosed |