Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CCR2 | P41597 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10970487 | 0.92 | MCHR1 (0.58) | SIGMAR1OPRK1MCHR1ROCK1ROCK2 | |
| Maleic Acid SCHEMBL10606750 | 0.91 | OPRK1 (0.56) | SIGMAR1OPRK1MCHR1ACHE | |
| Fumaric Acid SCHEMBL10606758 | 0.91 | OPRK1 (0.56) | SIGMAR1OPRK1MCHR1ACHE | |
| SCHEMBL10608375 | 0.88 | SIGMAR1 (0.61) | SIGMAR1GAASMN1; SMN2ACHEDRD4 | |
| SCHEMBL13462928 | 0.87 | OPRK1 (0.56) | SIGMAR1OPRK1MCHR1ROCK1ROCK2 | |
| SCHEMBL14163882 | 0.87 | BCHE (0.56) | OPRK1MCHR1ROCK1ROCK2GAA | |
| SCHEMBL10605824 | 0.87 | BCHE (0.56) | OPRK1MCHR1ROCK1ROCK2GAA | |
| SCHEMBL10607225 | 0.87 | OPRK1 (0.56) | SIGMAR1OPRK1MCHR1ROCK1ROCK2 | |
| SCHEMBL10607345 | 0.87 | OPRK1 (0.58) | SIGMAR1OPRK1MCHR1ROCK1ROCK2 | |
| SCHEMBL10607825 | 0.86 | HRH3 (0.62) | OPRK1MCHR1ROCK1ROCK2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0147909-B1 | ARYLOXY-N-(AMINOALKYL)-1-PYRROLIDINE AND PIPERIDINE CARBOXAMIDES AND CARBOTHIOAMIDES HAVING ANTIARRHYTHMIC ACTIVITY | A.H. ROBINS COMPANY, INCORPORATED (US) | 1989-12-06 | — | — | EP | disclosed |
| US-4547514-A | Aryloxy-N-(aminoalkyl)-1-pyrrolidine and piperidine carboxamides and carbothioamides having antiarrhythmic activity | A. H. ROBINS COMPANY, INCORPORATED (US) | 1985-10-15 | — | — | US | disclosed |
| EP-0147909-A1 | Aryloxy-N-(aminoalkyl)-1-pyrrolidine and piperidine carboxamides and carbothioamides having antiarrhythmic activity | A.H. ROBINS COMPANY, INCORPORATED (US) | 1985-07-10 | — | — | EP | disclosed |